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RAB0618
Human APOC3 / Apolipoprotein C-III ELISA Kit
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About This Item
Empfohlene Produkte
Speziesreaktivität
human
Verpackung
kit of 96 wells (12 strips x 8 wells)
Methode(n)
ELISA: suitable
Aufnahme
sample type plasma
sample type cell culture supernatant(s)
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2.5 pg/mL
standard curve range: 2.44-10000 pg/mL
Nachweisverfahren
colorimetric
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
human ... APOC3(345)
Allgemeine Beschreibung
The antibody pair provided in this kit recognizes Human Apolipoprotein C3.
ApoC-III is a glycoprotein that has 79 amino acids. It is coded by APOC3 gene. APOC3 is expressed in the liver and intestine. This gene is located on human chromosome 11.
ApoC-III is a glycoprotein that has 79 amino acids. It is coded by APOC3 gene. APOC3 is expressed in the liver and intestine. This gene is located on human chromosome 11.
Anwendung
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem./physiol. Wirkung
Apolipoprotein C-III (APOC3) has the ability to prevent lipoprotein lipase (LPL) and hepatic lipase activity. It is considered as a major modulator of triglyceride metabolism.
Sonstige Hinweise
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Signalwort
Warning
H-Sätze
P-Sätze
Gefahreneinstufungen
Met. Corr. 1
Lagerklassenschlüssel
8A - Combustible corrosive hazardous materials
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Scandinavian journal of clinical and laboratory investigation, 80(3), 230-235 (2020-02-29)
Apolipoprotein CIII (apoCIII) is associated with triglyceride (TG)-rich particles like VLDL and exerts an inhibitory effect of lipoprotein lipase. Increased levels are related to cardiovascular diseases and diabetes and therefore apoCIII has been proposed as a useful biomarker. Even if
Targeting APOC3 in the familial chylomicronemia syndrome.
The New England Journal of Medicine, 371(23), 2200-2206 (2014)
Biomedical research (Tokyo, Japan), 41(1), 33-42 (2020-02-25)
We investigated lipid metabolism in PXB-cells, which are human primary hepatocytes isolated from liver-humanized mice, and HepG2 and HuH-7 human hepatoma cell lines. Lipoprotein levels were higher in PXB-cells than in the 2 other cell lines, and PXB-cells mainly released
Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3.
Arteriosclerosis, Thrombosis, and Vascular Biology, 19(3), 472-484 (1999)
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.
Nature Medicine, 23(9), 1086-1086 (2017)
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