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RAB0235
Human IGFBP-3 ELISA Kit
for serum, plasma, cell culture supernatant and urine
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About This Item
UNSPSC-Code:
41116158
NACRES:
NA.32
Empfohlene Produkte
Speziesreaktivität
human
Verpackung
kit of 96 wells (12 strips x 8 wells)
Methode(n)
ELISA: suitable
capture ELISA: suitable
Aufnahme
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 74.07-18000 pg/mL
Nachweisverfahren
colorimetric
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
human ... IGFBP3(3486)
Allgemeine Beschreibung
The Human IGFBP-3 ELISA (Enzyme-Linked mmunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human IGFBP-3 in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Human IGFBP3
Anwendung
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem./physiol. Wirkung
Insulin-like growth factor-binding protein 3 (IGFBP3) is implicated in cell survival. In addition, it also facilitates cell death and tumorigenesis. Epigenetic changes in IGFBP3 affect non-small-cell lung cancer, hepatocellular carcinoma, ovarian cancer, skin cancer, urological cancers, breast cancer and gastric cancer. IGFBP3 is a primary growth inhibitor and can reverse the mitogenic functions of IGF-1 (insulin like growth factor 1) by inducing apoptosis.
Sonstige Hinweise
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit-Komponenten auch einzeln erhältlich
Produkt-Nr.
Beschreibung
SDB
Signalwort
Warning
H-Sätze
P-Sätze
Gefahreneinstufungen
Met. Corr. 1
Lagerklassenschlüssel
8A - Combustible corrosive hazardous materials
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The low IGFBP-3 level is associated with esophageal cancer patients: a meta-analysis.
Song G, et al.
World Journal of Surgical Oncology, 14(1), 307-307 (2016)
Insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTOR pathway in prostate cancer.
Du Y, et al.
Oncology, 34(5), 2273-2281 (2015)
Evaluation of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Expression Levels in Patients with Chronic Lymphocytic Leukemia.
Ayer M, et al.
Turkish journal of haematology : official journal of Turkish Society of Haematology, 33(4), 335-335 (2016)
Yan Wang et al.
Medical oncology (Northwood, London, England), 31(5), 921-921 (2014-03-29)
Growth factors in the brain are important to depression. We investigated the relationship between serum insulin-like growth factor (IGF-1) and IGF-binding protein-3 (IGFBP-3) concentration and risk of depression and the effect of psychological intervention on outcomes of high-grade glioma patients
Francesca D'Addio et al.
Nature communications, 13(1), 684-684 (2022-02-05)
Loss of pancreatic beta cells is a central feature of type 1 (T1D) and type 2 (T2D) diabetes, but a therapeutic strategy to preserve beta cell mass remains to be established. Here we show that the death receptor TMEM219 is
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