R9281

Rotigotin -hydrochlorid

≥98% (HPLC)

• Synonym(e): (−)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol hydrochloride, (−)-N 0437, N 0923, Neupro, SPM 962
• Empirische Formel (Hill-System): C₁₉H₂₅NOS·HCl
• CAS-Nummer: 125572-93-2
• Molekulargewicht: 351.93
• MDL-Nummer: MFCD00906149
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824046
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Löslichkeit: DMSO: >10 mg/mL
• Ersteller: UCB Inc.
• Lagertemp.: room temp
• SMILES String: Cl.CCCN(CCc1cccs1)[C@H]2CCc3c(O)cccc3C2
• InChI: 1S/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H/t16-;/m0./s1
• InChIKey: CEXBONHIOKGWNU-NTISSMGPSA-N

Beschreibung

Biochem./physiol. Wirkung

Rotigotine hydrochloride is a non-ergolinic D3/D2 and D1-dopamine agonist. It is appropriate for transdermal delivery through skin patches, that has the drug in a silicone-based adhesive matrix.

Rotigotine is a dopamine receptor agonist with preference for D₃ receptors over D₂ and D₁. As such, it is an effective anti-Parkinsonian agent. Racemic rotigotine is about 50 times as potent as quinpirole, the gold standard D₂ agonist.

Leistungsmerkmale und Vorteile

This compound was developed by UCB Inc.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable