Q2128

Quisqualinsäure

powder

• Synonym(e): 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanin
• Empirische Formel (Hill-System): C₅H₇N₃O₅
• CAS-Nummer: 52809-07-1
• Molekulargewicht: 189.13
• Beilstein: 1078734
• MDL-Nummer: MFCD00069337
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24278004
• NACRES: NA.32

Eigenschaften

• Form: powder
• Qualitätsniveau: 200
• Farbe: white to off-white
• Löslichkeit: ethanol: <0.17 mg/mL; H₂O: 0.5 mg/mL; 0.1 M HCl: 1.4 mg/mL; 1 M NH4OH: 20 mg/mL; organic solvents: insoluble
• Lagertemp.: 2-8°C
• SMILES String: N[C@@H](CN1OC(=O)NC1=O)C(O)=O
• InChI: 1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
• InChIKey: ASNFTDCKZKHJSW-REOHCLBHSA-N
• Angaben zum Gen: rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm4(24417) , Grm5(24418)

Beschreibung

Allgemeine Beschreibung

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

Anwendung

Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.

Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.

Biochem./physiol. Wirkung

Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves