P4157

Phe-Arg β-naphthylamide dihydrochloride

cathepsin substrate, fluorogenic, ≥98% (TLC), powder

• Synonym(e): PAβN
• Empirische Formel (Hill-System): C₂₅H₃₀N₆O₂ · 2HCl
• CAS-Nummer: 100929-99-5
• Molekulargewicht: 519.47
• MDL-Nummer: MFCD00058046
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 24898508
• NACRES: NA.32

Eigenschaften

• product name: Phe-Arg β-naphthylamide dihydrochloride, cathepsin substrate
• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• Löslichkeit: water: 50 mg/mL, clear, colorless to faintly yellow
• Lagertemp.: −20°C
• SMILES String: Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2
• InChI: 1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H
• InChIKey: ZMTAZQYLEGNUTJ-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Phe-Arg β-naphthylamide, a peptidomimetic compound, is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.

Anwendung

Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrate

Substrate for dipeptidyl aminopeptidase I (cathepsin C).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)