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N7787

Sigma-Aldrich

NS3694

≥98%, powder

Synonym(e):

4-Chloro-2-[3-(3-trifluoromethyl-phenyl)-ureido]benzoic acid

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About This Item

Empirische Formel (Hill-System):
C15H10ClF3N2O3
CAS-Nummer:
426834-38-0
Molekulargewicht:
358.70
MDL-Nummer:
MFCD00249000
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724557
NACRES:
NA.77

Assay

≥98%

Form

powder

Löslichkeit

DMSO: soluble 22 mg/mL
H2O: insoluble <5 mg/mL

Lagertemp.

2-8°C

SMILES String

OC(=O)c1ccc(Cl)cc1NC(=O)Nc2cccc(c2)C(F)(F)F

InChI

1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)

InChIKey

GNCZTZCPXFDPLI-UHFFFAOYSA-N

Angaben zum Gen

human ... GRIK1(2897)

Anwendung

NS3694 may be used as an apoptosis inhibitor to study the relationship between the cellular mechanisms controlled by amputation-induced myeloid lineage activity.

Biochem./physiol. Wirkung

NS3694 can prevent the active apoptosome complex formation.
NS3694 is an Inhibitor of apoptosome formation.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Developmental dependence for functional eye regrowth in Xenopus laevis.
Cindy X Kha et al.
Neural regeneration research, 13(10), 1735-1737 (2018-08-24)
Cindy X Kha et al.
Experimental eye research, 169, 38-47 (2018-01-23)
Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration. However, it has been reported
Jovany J Franco et al.
Molecular biology of the cell, 30(16), 1890-1899 (2019-02-21)
Epithelial wound healing requires a complex orchestration of cellular rearrangements and movements to restore tissue architecture and function after injury. While it is well known that mechanical forces can affect tissue morphogenesis and patterning, how the biophysical cues generated after
Ulrik Lademann et al.
Molecular and cellular biology, 23(21), 7829-7837 (2003-10-16)
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the formation of a caspase-activating protein complex called the apoptosome, whereas
Can Aztekin et al.
Development (Cambridge, England), 147(3) (2020-01-29)
Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms affected by immune cells and inflammation can help develop strategies to promote tissue repair and regeneration. Here, we took advantage of naturally occurring tail
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