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N2288

Sigma-Aldrich

Nefiracetam

solid

Synonym(e):

(2-(2-oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384

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About This Item

Empirische Formel (Hill-System):
C14H18N2O2
CAS-Nummer:
77191-36-7
Molekulargewicht:
246.30
MDL-Nummer:
MFCD00209882
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329818410
NACRES:
NA.77

Form

solid

Qualitätsniveau

100

Farbe

white to off-white

Löslichkeit

DMSO: >5 mg/mL

SMILES String

Cc1cccc(C)c1NC(=O)CN2CCCC2=O

InChI

1S/C14H18N2O2/c1-10-5-3-6-11(2)14(10)15-12(17)9-16-8-4-7-13(16)18/h3,5-6H,4,7-9H2,1-2H3,(H,15,17)

InChIKey

NGHTXZCKLWZPGK-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Nefiracetam (NEF) is a pyrrolidonetype nootropic agent with various pharmacologic as well as cognition enhancing effects. In amygdala-kindled seizures, nefiracetam inhibits both electroencephalographic and behavioral seizures. NEF has a distinct anticonvulsant spectrum.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Yijin Yan et al.
Behavioural brain research, 173(1), 39-46 (2006-07-22)
Animal models of drug discrimination have been used to examine the subjective effects of addictive substances. The cAMP system is a crucial downstream signaling pathway implicated in the long-lasting neuroadaptations induced by addictive drugs. We examined effects of rolipram, nefiracetam
Ricardo E Jorge et al.
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 55(6), 350-354 (2010-06-15)
We will review the available evidence on the frequency, clinical correlates, mechanism, and treatment of apathy following stroke. We have explored relevant databases (that is, PubMed, MEDLINE, and PsycINFO) using the following key words and their combinations: apathy, motivation, abulia
Robert G Robinson et al.
The Journal of neuropsychiatry and clinical neurosciences, 20(2), 178-184 (2008-05-03)
In preliminary trials, nefiracetam, a gamma aminobutyric compound, enhanced blood flow and improved mood following stroke. Within 3 months following stroke with major depression, 159 patients were enrolled in a double-blind trial of nefiracetam or placebo. Repeated measures analysis of
Shigeki Moriguchi et al.
Journal of neurochemistry, 106(3), 1092-1103 (2008-05-01)
Nefiracetam is a pyrrolidine-related nootropic drug exhibiting various pharmacological actions such as cognitive-enhancing effect. We previously showed that nefiracetam potentiates NMDA-induced currents in cultured rat cortical neurons. To address questions whether nefiracetam affects NMDA receptor-dependent synaptic plasticity in the hippocampus
Yoshimi Tsuchiya et al.
Toxicologic pathology, 33(5), 561-569 (2005-08-18)
To ascertain the early pathophysiological features in canine renal papillary necrosis (RPN) caused by the neurotransmission enhancer nefiracetam, male beagle dogs were orally administered nefiracetam at 300 mg/kg/day for 4 to 7 weeks in comparison with ibuprofen, a non-steroidal anti-inflammatory
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