N129

Naloxone methiodide

≥98% (HPLC), solid

• Synonym(e): (5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide, N-Methylnaloxonium iodide
• Empirische Formel (Hill-System): C₂₀H₂₄INO₄
• CAS-Nummer: 93302-47-7
• Molekulargewicht: 469.31
• MDL-Nummer: MFCD00078592
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24897480
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Arzneimittelkontrolle: regulated under CDSA - not available from Sigma-Aldrich Canada
• Farbe: white to tan
• Löslichkeit: H₂O: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: [I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34
• InChI: 1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1
• InChIKey: ICONPJDAXITIPI-UXYWFNEESA-N

Beschreibung

Anwendung

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.

Biochem./physiol. Wirkung

Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.

Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves