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M3199

Sigma-Aldrich

MK-212 hydrochloride

≥98% (HPLC)

Synonym(e):

2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride, 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, NSC 31732

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About This Item

Empirische Formel (Hill-System):
C8H11ClN4·HCl
CAS-Nummer:
61655-58-1
Molekulargewicht:
235.11
EG-Nummer:
262-883-0
MDL-Nummer:
MFCD00673963
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329817966
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to off-white

Löslichkeit

DMSO: ≥20 mg/mL

Lagertemp.

2-8°C

SMILES String

Cl.Clc1cncc(n1)N2CCNCC2

InChI

1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H

InChIKey

PFIZGLUIYAZQFU-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Selective 5-HT2C serotonin receptor agonist.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Die Dokumentenbibliothek aufrufen

Adriane M dela Cruz et al.
Behavioural pharmacology, 20(8), 720-730 (2009-11-11)
Only a subgroup of human drug users progress from initial drug taking to drug addiction. The learned associations between the effects of the drug and the environment in which it is experienced is an important aspect of the progression to
M L Pierce et al.
Neuroscience, 170(3), 827-838 (2010-07-24)
Neuronal networks generating rhythmic activity as an emergent property are common throughout the nervous system. Some are responsible for rhythmic behaviours, as is the case for the spinal cord locomotor networks; however, for others the function is more subtle and
N K Popova et al.
Neuroscience and behavioral physiology, 40(4), 357-361 (2010-03-26)
The functional activity of serotonin 5-HT(2A) and 5-HT(2C) receptors and the expression of the genes encoding them were studied in Norway rats bred for 60 generations for the presence and absence of high levels of stress-evoked aggression to humans. There
Martilias Farrell et al.
Psychopharmacology, 211(2), 149-159 (2010-06-08)
The extended ternary complex theory of receptor function states a ligand can be classified as an inverse agonist, agonist, or neutral antagonist based on its ability to preferentially stabilize the inactive conformation, the active conformation, or to have no preference
E G Kuznetsova et al.
Bulletin of experimental biology and medicine, 142(5), 594-597 (2007-04-07)
A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of
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