K1136

Ketorolac Tris-salz

≥99%, crystalline

• Synonym(e): (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-carbonsäure, Toradol
• Empirische Formel (Hill-System): C₁₅H₁₃NO₃ · C₄H₁₁NO₃
• CAS-Nummer: 74103-07-4
• Molekulargewicht: 376.40
• MDL-Nummer: MFCD00887595
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24278503
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 100
• Assay: ≥99%
• Form: crystalline
• Löslichkeit: H₂O: soluble 15 mg/mL, clear, colorless to faintly yellow (stable at least one month at −20 °C.)
• Lagertemp.: room temp
• SMILES String: NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
• InChI: 1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
• InChIKey: BWHLPLXXIDYSNW-UHFFFAOYSA-N
• Angaben zum Gen: human ... PTGS1(5742) , PTGS2(5743)

Beschreibung

Anwendung

Ketorolac has been used:

• as an intraperitoneal injection in mice to study the effect of ketorolac on expression of c-Fos (a human proto-oncogene) in ARC (arcuate nucleus of the hypothalamus) POMC (proopiomelanocortin) -EGFP (enhanced green fluorescent protein) neurons
• to treat mice in order to show that this treatment does not prevent IL-1β-mediated inhibition of Agouti-related protein (AgRP) secretion from murine hypothalamic explants
• as an analgesic medication to treat rats induced with acute inflammatory joint injury by injecting carrageenan into the ankle

Biochem./physiol. Wirkung

Ketorolac is a non-steroidal agent that possesses moderate anti-inflammatory activity and is also a potent analgesic. It shows superior analgesic efficacy to that of the opioid analgesics like morphine in patients with moderate to severe postsurgical pain. It inhibits prostaglandin synthesis and platelet aggregation induced by arachidonic acid and collagen. It is a dual COX-1/COX-2 inhibitor.

Vorsicht

Stable at least 2 years if stored at room temperature.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H315,H319,H335
• P-Sätze: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges