J4455

JSH-23

≥98% (HPLC), solid

• Synonym(e): 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
• Empirische Formel (Hill-System): C₁₆H₂₀N₂
• CAS-Nummer: 749886-87-1
• Molekulargewicht: 240.34
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: protect from light
• Farbe: off-white to gray-pink
• Löslichkeit: DMSO: >10 mg/mL
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• InChI: 1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
• InChIKey: YMFNPBSZFWXMAD-UHFFFAOYSA-N

Beschreibung

Anwendung

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Biochem./physiol. Wirkung

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Sonstige Hinweise

Light and air sensitive.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3