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I1142

Sigma-Aldrich

Monoclonal Anti-Interferon-γ antibody produced in rat

clone 37895, purified immunoglobulin, lyophilized powder

Synonym(e):

Anti-IFN-γ

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About This Item

MDL-Nummer:
MFCD00165744
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rat

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

37895, monoclonal

Form

lyophilized powder

Speziesreaktivität

mouse

Methode(n)

flow cytometry: suitable
neutralization: suitable
western blot: suitable

Isotyp

IgG2a

UniProt-Hinterlegungsnummer

P01580

Lagertemp.

−20°C

Angaben zum Gen

mouse ... Ifng(15978)

Verwandte Kategorien

Allgemeine Beschreibung

Interferon-γ (IFN-γ) belongs to Type II class of interferons and is produced by T helper cells (specifically, Th1 cells), natural killer (NK) and natural killer T (NKT) cells and cytotoxic T cells (TC cells) . It has various biological functions including antiviral activity like inhibition of cell or tumor growth, act as a potent modulator of immune responses and modifies cellular processes as well as stimulates the differentiation of B cells into immunoglobulin-producing cells. Monoclonal Anti-Interferon-γ antibody can be used in immunoblotting. Rat anti-Interferon-γ antibody has shown no cross-reactivity for recombinant human IFN-γ or recombinant rat IFN-γ.

Spezifität

The antibody does not cross-react with recombinat human IFN-γ or recombinant rat IFN-γ.

Immunogen

recombinant mouse IFN-γ.

Anwendung

Monoclonal Anti-Interferon-γ antibody can be used in neutralization and indirect ELISA.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline and 5% trehalose.

Angaben zur Herstellung

Purified from cell culture supernatant using protein G.

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

Lot/Batch Number
0000334085
0000272803
0000282894
SLCC4859
059H0258

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I Gresser et al.
Proceedings of the National Academy of Sciences of the United States of America, 66(4), 1052-1058 (1970-08-01)
Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells in stationary suspension cultures. The degree of inhibition was found to correlate with the antiviral titer of the interferon preparations. The factor(s) responsible for inhibition of L 1210
J Vilcek et al.
Journal of immunology (Baltimore, Md. : 1950), 135(3), 1851-1856 (1985-09-01)
Interferon (IFN)-gamma production, stimulated by the addition of exogenous interleukin (IL) 2, T cell mitogens, or tuberculin purified protein derivative (PPD) was studied in cultures of separated human mononuclear cells or unseparated peripheral blood leukocytes (PBL). IFN-gamma was induced by
P D Benech et al.
The Journal of experimental medicine, 176(4), 1115-1123 (1992-10-01)
The human Fc gamma RI (CD64) is a high affinity receptor for the Fc portion of immunoglobulin (Ig), and its constitutively low expression on the cell surface of monocyte/macrophage and neutrophils is selectively upregulated by interferon gamma (IFN-gamma) treatment (Perussia
P B Fisher et al.
Pharmacology & therapeutics, 27(2), 143-166 (1985-01-01)
As described in this review, both partially purified and recombinant interferons are potent modulators of differentiation in diverse cell culture systems (Table 2). Depending on the target cell, interferon exerts either an inhibitory or an inductive effect on cell differentiation.
Jamie R Schoenborn et al.
Advances in immunology, 96, 41-101 (2007-11-06)
Interferon-gamma (IFN-gamma) is crucial for immunity against intracellular pathogens and for tumor control. However, aberrant IFN-gamma expression has been associated with a number of autoinflammatory and autoimmune diseases. This cytokine is produced predominantly by natural killer (NK) and natural killer

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