E9658

Enalaprilat Dihydrat

≥98% (HPLC)

• Synonym(e): (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]-amino]-propanoyl]-pyrrolidin-2-carbonsäure
• Empirische Formel (Hill-System): C₁₈H₂₄N₂O₅ ·2H₂O
• CAS-Nummer: 84680-54-6
• Molekulargewicht: 384.42
• EG-Nummer: 278-459-3
• MDL-Nummer: MFCD00941393
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329799089
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Löslichkeit: H₂O: 14 mg/mL at 60 °C (warming for 5 minutes); DMSO: 64 mg/mL
• Ersteller: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Lagertemp.: room temp
• SMILES String: O.O.C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1
• InChIKey: MZYVOFLIPYDBGD-MLZQUWKJSA-N
• Angaben zum Gen: human ... ACE(1636)

Beschreibung

Biochem./physiol. Wirkung

Enalapril, the ethyl ester of enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to enalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.

Enalaprilat is an inhibitor of angiotensin converting enzyme (ACE), antihypertensive, and a Bradykinin B1 receptor activator. Enalaprilat has nM potency versus ACE and also activates B1 receptors to release NO.

Leistungsmerkmale und Vorteile

This compound is featured on the Angiotensin Receptors and Bradykinin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)