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Wichtige Dokumente
E9034
Phosphodiesterase 5A1 human
recombinant, expressed in Sf9 cells
Synonym(e):
3′,5′-cyclic-GMP phosphodiesterase, PDE 5A1
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About This Item
Empfohlene Produkte
Rekombinant
expressed in Sf9 cells
Qualitätsniveau
Form
solution
Spezifische Aktivität
≥2,000 unit/μg protein
Mol-Gew.
126 kDa
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... PDE5A(8654)
Allgemeine Beschreibung
Research area: Cell SignallingPDE5is located in various tissues such as the kidney, brain, lungs, cardiac myocytes,vascular smooth muscle cells, penile corpus cavernosum, platelets, andgastrointestinal tissues.
Biochem./physiol. Wirkung
PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis . Phosphodiesterase (PDE)is an enzyme that is used to break phosphodiester bonds. Phosphodiesterase 5 (PDE5), amolecular target for the treatment of erectile dysfunction and pulmonaryhypertension. PDE5 is used to find novel PDE5 inhibitors. PDE5 specifically targets cyclicguanosine monophosphate (cGMP) generated by the activation of nitric oxide (NO). PDE5 regulates cGMP signalingin the cardiovascular and other tissues. At the genetic level PDE5 isexpressed as various isoforms and undergoes phosphorylation as a post-translationalmodification that results in its activation. PDE5 is degraded through theubiquitin pathway due to its nitrosylation.
Physikalische Eigenschaften
N-terminal GST-tagged 126 kDa full-length protein
Einheitendefinition
One unit will convert 1.0 picomole of 3′,5′-cGMP to 5′-GMP per minute at pH 7.4 at 37 °C.
Physikalische Form
Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% TWEEN® 20 and 3 mM DTT
Rechtliche Hinweise
TWEEN is a registered trademark of Croda International PLC
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Felicia Akuamoa et al.
Toxicology in vitro : an international journal published in association with BIBRA, 73, 105130-105130 (2021-03-05)
Herbal supplements sold as 'all natural' on various markets in Accra (Ghana) and advertised as highly efficacious in treating erectile dysfunction (ED) were bought and analysed by a PDE-5 enzyme inhibition assay. The claimed efficacy of these products could be
Wesam S Ahmed et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 134, 111128-111128 (2020-12-22)
Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases (PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated activation of the soluble guanylyl cyclase. Given the crucial role of cGMP generated through the activation of this cellular
Andrew T Bender et al.
Pharmacological reviews, 58(3), 488-520 (2006-09-14)
Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There are 11 different PDE families, with each family typically having several different isoforms and splice
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