C8031

N⁶-Cyclopentyladenosine

solid

• Synonym(e): CPA
• Empirische Formel (Hill-System): C₁₅H₂₁N₅O₄
• CAS-Nummer: 41552-82-3
• Molekulargewicht: 335.36
• MDL-Nummer: MFCD00036845
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277686
• NACRES: NA.77

Eigenschaften

• Form: solid
• Qualitätsniveau: 200
• Farbe: white to off-white
• Löslichkeit: H₂O: 1.7 mg/mL; 0.1 M HCl: 12 mg/mL; DMSO: 23 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCC4)ncnc23
• InChI: 1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1
• InChIKey: SQMWSBKSHWARHU-SDBHATRESA-N
• Angaben zum Gen: human ... ADORA1(134) , ADORA2A(135) , ADORA3(140) ; mouse ... Adora1(11539) ; rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)

Beschreibung

Anwendung

N⁶-Cyclopentyladenosine has also been used to study its effect on p53 and caspase 3, 8, and 9 expression and apoptosis rate in MCF-7 breast cancer cell line.

N⁶-Cyclopentyladenosine has been used to study its effect on the cavernosal smooth muscle cells from lean and db/db (obesity and type II diabetes caused by a leptin receptor mutation) mice.

Biochem./physiol. Wirkung

N⁶-Cyclopentyladenosine (CPA) is an adenosine derivative and a potent A1 adenosine receptor agonist. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.

N⁶-Cyclopentyladenosine also exhibits analgesic effect against acute, arthritis-induced and neuropathic pain.

Leistungsmerkmale und Vorteile

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Physikalische Form

hygroscopic solid

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)