C3743

CI 976

>98% (HPLC), solid

• Synonym(e): 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
• Empirische Formel (Hill-System): C₂₃H₃₉NO₄
• CAS-Nummer: 114289-47-3
• Molekulargewicht: 393.56
• MDL-Nummer: MFCD00869662
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329775044
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: >98% (HPLC)
• Form: solid
• Löslichkeit: DMSO: >10 mg/mL; H₂O: insoluble <2 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
• InChI: 1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
• InChIKey: WAFNZAURAWBNDZ-UHFFFAOYSA-N

Beschreibung

Anwendung

CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:

• to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
• to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
• to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells

Biochem./physiol. Wirkung

CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

Sicherheitshinweise

• H-Sätze: H413
• P-Sätze: P273 - P501
• Gefahreneinstufungen: Aquatic Chronic 4
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)