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C3412

Sigma-Aldrich

Cyproteronacetat

≥98%

Synonym(e):

6-Chlor-1β,2β-dihydro-17-hydroxy-3′H-cyclopropa[1,2]pregna-1,4,6-trien-3,20-dion-acetat

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About This Item

Empirische Formel (Hill-System):
C24H29ClO4
CAS-Nummer:
427-51-0
Molekulargewicht:
416.94
EG-Nummer:
207-048-3
MDL-Nummer:
MFCD00864671
UNSPSC-Code:
41116107
PubChem Substanz-ID:
24278309
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98%

Form

powder

Lagertemp.

2-8°C

SMILES String

[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]34C

InChI

1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1

InChIKey

UWFYSQMTEOIJJG-FDTZYFLXSA-N

Angaben zum Gen

human ... AR(367) , NR3C1(2908) , PGR(5241)
mouse ... Nr3c1(14815)
rat ... Ar(24208)

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Anwendung

Cyproterone acetate has been used to study its effects on insulin-like growth factor I secretion.

Biochem./physiol. Wirkung

Cyproterone acetate is a synthetic steroid and an androgen antagonist. It is a potent inhibitor of leukocyte migration through endothethial cell monolayers. Cyproterone acetate acts as a liver tumor promoter in experimental animal model. Liver tumor promotion appears to be female gender-specific, as formation of an active metabolite that forms DNA adducts.

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Benzylbenzoat tested according to Ph. Eur.

Sigma-Aldrich

12392

Benzylbenzoat

Eplerenon ≥98% (HPLC)

Sigma-Aldrich

E6657

Eplerenon

Estron ≥99%

Sigma-Aldrich

E9750

Estron

Spironolacton 97.0-103.0%

Sigma-Aldrich

S3378

Spironolacton

17α-Ethinylestradiol ≥98%

Sigma-Aldrich

E4876

17α-Ethinylestradiol

β-Estradiol ≥98%

Sigma-Aldrich

E8875

β-Estradiol

Progesteron ≥99%

Sigma-Aldrich

P0130

Progesteron

M J Tucker et al.
Carcinogenesis, 17(7), 1473-1476 (1996-07-01)
The synthetic progestin cyproterone acetate (CPA) has been shown to be a hepatocarcinogen in the rat, but little is known of its effects in mice. A 52 week CPA study in the mouse strain C57Bl/10J has been reported not to
R Hofbauer et al.
Fertility and sterility, 72(4), 652-656 (1999-10-16)
To investigate the influence of ethinyl estradiol and cyproterone acetate in oral contraceptives on leukocyte migration through endothelial cell monolayers. Experimental in vitro prospective study. An academic research laboratory. Endothelial cells were cultured on microporous membranes to produce monolayers. Polymorphonuclear
Cara L Benjamin et al.
The Journal of steroid biochemistry and molecular biology, 91(3), 111-119 (2004-07-28)
Skeletal muscle has long been thought to be a target tissue for androgens, eliciting their effect through the androgen receptor. In order to better understand androgen receptor action, a series of mutated androgen receptors were developed and their degree of
Cyproterone, norethindrone, medroxyprogesterone and levonorgestrel are less potent local human growth hormone and insulin-like growth factor I secretion stimulators than progesterone in human breast cancer explants expressing the estrogen receptor
Milewicz T, et al.
Gynecological Endocrinology, 16(4), 319-329 (2002)
Cody J Dey et al.
Hormones and behavior, 58(4), 599-605 (2010-07-10)
Proximate mediators of reproductive behaviors in vertebrates have a long history of study. In fishes, relatively few studies have focused on hormonal control of parental care, despite a comprehensive background on the general physiology of fishes, and the frequent occurrence
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