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Merck

C3175

Sigma-Aldrich

Chloramphenicol-Water Soluble

powder, suitable for cell culture, BioReagent

Synonym(e):

Chloramphenicol, Chlornitromycin, Chlorocid, Chloromycetin, Cloramfenicol, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, Chloromycetin, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]aceta, Kloramfenikol

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About This Item

UNSPSC-Code:
12352207
NACRES:
NA.76
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Produktbezeichnung

Chloramphenicol-Water Soluble, powder, BioReagent, suitable for cell culture

Produktlinie

BioReagent

Qualitätsniveau

Form

powder

Methode(n)

cell culture | mammalian: suitable

Löslichkeit

H2O: 50-500 mg/mL (stock solution)
PBS: 50-500 mg/mL (stock solution)
other salt solutions: not recommended

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

Wirkungsweise

protein synthesis | interferes

Anwendung

Chloramphenicol-Water Soluble has been used:

  • as a supplement in Luria-Bertani (LB) medium to culture Escherichia coli[1]
  • as a supplement in LB agar to culture Citrobacter rodentium[2]
  • to culture Toxoplasma gondii[3]

Biochem./physiol. Wirkung

Chloramphenicol is a natural product found in Streptomyces venezuelae.[4] It shows a broad range of antibiotic activity against Gram-negative and Gram-positive bacteria by binding to the peptidyl transferase loop of the ribosomal RNA to block the peptide bond formation.[5][6]

Verpackung

Package size based on chloramphenicol

Sonstige Hinweise

Formulated to contain approx. 100 mg chloramphenicol per gram of powder; balance 2-hydroxypropyl-β-cyclodextrin.
Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Keep in a dry place.

Piktogramme

Health hazardCorrosion

Signalwort

Danger

Gefahreneinstufungen

Carc. 2 - Eye Dam. 1 - Repr. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

A Chatzitakis et al.
Water research, 42(1-2), 386-394 (2007-08-19)
The photocatalytic degradation of Chloramphenicol, an antibiotic drug, has been investigated in aqueous heterogeneous solutions containing n-type oxide semiconductors as photocatalysts. The disappearance of the organic molecule follows approximately a pseudo-first-order kinetics according to the Langmuir-Hinshelwood model. It was observed
D H Burke et al.
Chemistry & biology, 4(11), 833-843 (1998-01-31)
The problem of how macromolecules adopt specific shapes to recognize small molecules in their environment is readily addressed through in vitro selections (the SELEX protocol). RNA-antibiotic interactions are particularly attractive systems for study because they provide an opportunity to expand
Jaap C Hanekamp et al.
Environmental toxicology and pharmacology, 39(1), 213-220 (2014-12-22)
The antibiotic chloramphenicol (CAP) is banned from food production. Besides being a medicinal product, CAP is also a natural product, produced by Streptomyces Venezuelae. The lack of scientific data hampers setting of an Acceptable Daily Intake (ADI). Consequently, a maximum
Valerie F Crepin et al.
Nature protocols, 11(10), 1851-1876 (2016-09-09)
Infection of mice with Citrobacter rodentium is a robust model to study bacterial pathogenesis, mucosal immunology, the health benefits of probiotics and the role of the microbiota during infection. C. rodentium was first isolated by Barthold from an outbreak of
Taru Hilander et al.
Nucleic acids research, 46(2), 849-860 (2017-12-12)
Accuracy of protein synthesis is enabled by the selection of amino acids for tRNA charging by aminoacyl-tRNA synthetases (ARSs), and further enhanced by the proofreading functions of some of these enzymes for eliminating tRNAs mischarged with noncognate amino acids. Mouse

Questions

1–2 of 2 Questions  
  1. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. How do I calculate the molarity of product C3175, Chloramphenicol-Water Soluble?

    1 answer
    1. Product C3175 (Chloramphenicol-Water Soluble) is a complex of chloramphenicol and cyclodextrin. Cyclodextrin is used to aid in the solubility of chloramphenicol into water. In order to prepare a molar solution of chloramphenicol you will have to base it on the chloramphenicol content in the solution and not the entire complex.  Product C3175 is formulated to contain approximately 100 mg chloramphenicol per gram of powder.  Based on this average, if you are preparing a 500 mg/ml stock solution, there will be approximately 50 mg of chloramphenicol in 1 ml.  Below is the calculated molarity of chloramphenicol when the complex is dissolved at 500 mg/ml in water. molecular weight X unknown molarity X volume = complex weight X complex ratio323.13 g/mol X Molarity X 1 ml = 500 mg X 0.1           Molarity = 0.155 Mchloramphenicol molecular weight = 323.13 g/molmolarity (unknown) = mol/Lvolume = 1mlcomplex weight = 500 mgcomplex ratio = 100 mg chloramphenicol/1 gm complex

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