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B1434

Sigma-Aldrich

BMP7, human

>95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

Synonym(e):

BMP-7, OP-1, Osteogenic protein 1

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About This Item

MDL-Nummer:
MFCD03702812
UNSPSC-Code:
12352202
NACRES:
NA.32

product name

Bone Morphogenetic Protein 7 human, >95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

Biologische Quelle

human

Qualitätsniveau

100

Rekombinant

expressed in CHO cells

Assay

>95% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

0.2-0.6 μg/mL ED50

Mol-Gew.

monomer calculated mol wt 15.7 kDa
 18-20 kDa by SDS-PAGE (reducing)
 30-40 kDa by SDS-PAGE (non-reducing)

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

endotoxin, tested

UniProt-Hinterlegungsnummer

P18075

Lagertemp.

−20°C

Angaben zum Gen

human ... BMP7(655)

Biochem./physiol. Wirkung

Cellular responses to BMP-7 are mediated by the formation of hetero-oligomeric complexes of type I and II serine/threonine kinase receptors. Human and mouse BMP-7 share 98% amino acid sequence identity.

Physikalische Form

Lyophilized from 50.0 μl of a 0.2 μm filtered solution in 35% acetonitrile, 0.1% TFA containing 50 μg bovine serum albumin per 1μg of cytokine.

Hinweis zur Analyse

The biological activity is measured by its ability to induce alkaline phosphatase production using mouse ATDC-5 chondrogenic cells.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H315,H319

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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A H Reddi
Nature biotechnology, 16(3), 247-252 (1998-04-07)
Morphogenesis is the developmental cascade of pattern formation and body plan establishment, culminating in the adult form. It has formed the basis for the emerging discipline of tissue engineering, which uses principles of molecular developmental biology and morphogenesis gleaned through
Effat Karimi Ghahfarrokhi et al.
The archives of bone and joint surgery, 9(5), 585-597 (2021-10-26)
Healing of large segmental bone defects can be challenging for orthopedic surgeons. This research was conducted to provide further insight into the effects of BMP7 in combination with autograft and platelet fibrin glue (PFG) on bone regeneration by Masquelet technique
A J Celeste et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(24), 9843-9847 (1990-12-01)
Characterization of the polypeptides present in bone-inductive protein extracts from bovine bone has led to the cloning of seven regulatory molecules, six of which are distantly related to transforming growth factor beta. The three human bone morphogenetic proteins (BMPs) we
Yan Wang et al.
Experimental and molecular pathology, 98(3), 393-402 (2015-03-17)
This study presented the effect of bone morphogenic protein-7 (BMP-7) inhibiting epithelial-mesenchymal transition (EMT) in silicosis model. In vivo, Wistar rats were exposed to silica by intratracheal instillation. Seven days later rats were treated with BMP-7. Rats were sacrificed at
Endre Kristóf et al.
Scientific reports, 5, 12540-12540 (2015-07-28)
Laser-scanning cytometry is presented as a tool allowing population scale analysis of ex vivo human brown adipogenic differentiation. It combines texture analysis and detection of Ucp1 protein content in single brown adipocytes of mixed cell populations with gene expression pattern
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