AV31592

Anti-AEBP1 antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-AE binding protein 1
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 131 kDa
• Speziesreaktivität: rabbit, horse, guinea pig, rat, human
• Konzentration: 0.5 mg - 1 mg/mL
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_001120
• UniProt-Hinterlegungsnummer: Q8IUX7
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... AEBP1(165)

Beschreibung

Allgemeine Beschreibung

AEBP1 is a transcriptional repressor that negatively regulates PTEN. This transcription factor is involved in adipocyte growth and is a sex-specific risk factor for diet-induced obesity. Furthermore, AEBP1 is also known to have proinflammatory roles in macrophages.
Rabbit Anti-AEBP1 antibody recognizes human, mouse, rat, and pig AEBP1.

The previously assigned protein identifier Q14113 has been merged into Q8IUX7. Full details can be found on the UniProt database.

Immunogen

Synthetic peptide directed towards the N terminal region of human AEBP1

Anwendung

Rabbit Anti-AEBP1 antibody can be used for immunohistochemical assays at concentration of 4-8μg/ml. It can also be used for western blot (0.2-5.0μg/ml) applications.

Biochem./physiol. Wirkung

The adipocyte enhancer binding protein 1 (AEBP1) is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. AEBP1 may play a role in differentiated vascular smooth muscle cells.

Sequenz

Synthetic peptide located within the following region: VPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEK

Physikalische Form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable