A6150

α₁-Antitrypsin aus Humanplasma

salt-free, lyophilized powder

• Synonym(e): α₁-Proteinase-Inhibitor
• CAS-Nummer: 9041-92-3
• EG-Nummer: 232-924-7
• MDL-Nummer: MFCD00130469
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: human plasma
• Qualitätsniveau: 200
• Form: salt-free, lyophilized powder
• Konzentration: ≥60% (biuret)
• Methode(n): inhibition assay: suitable
• UniProt-Hinterlegungsnummer: P01009; P08246
• Lagertemp.: 2-8°C
• Angaben zum Gen: human ... ELA2(1991) , ELANE(1991) , SERPINA1(5265)

Beschreibung

Biochem./physiol. Wirkung

≤10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. ≤10 mg will inhibit approx. 1.0 mg of ·α-chymotrypsin with activity of 40-50 BTEE units per mg protein.

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α₁-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α₁-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.

Vorsicht

Wässrige Stammlösungen mit 0.01% NaN₃ sind mehrere Monate lang stabil Die Lösungen können bei -80°C aufbewahrt werden, sollten aber nach dem Auftauen nicht wieder eingefroren werden. Instabil unterhalb pH 5.5. Wird inaktiviert durch einige non-serine Proteasen und durch Oxidation der Methionin Seitenkette des aktiven Zentrums.

Angaben zur Herstellung

Chromatographically prepared and partially purified.

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable