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Merck

A255

Sigma-Aldrich

A-77636 hydrochloride hydrate

≥98% (HPLC), solid

Synonym(e):

(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate

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About This Item

Empirische Formel (Hill-System):
C20H27NO3 · HCl · xH2O
CAS-Nummer:
Molekulargewicht:
365.89 (anhydrous basis)
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Qualitätsniveau

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

desiccated
protect from light

Farbe

white to off-white

Löslichkeit

H2O: >10 mg/mL

Lagertemp.

−20°C

SMILES String

O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4

InChI

1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1

InChIKey

KNACNUUSUYTFDY-LIWDBWMRSA-N

Angaben zum Gen

human ... DRD1(1812)

Biochem./physiol. Wirkung

Potent, orally active D1 dopamine receptor agonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.

Rechtliche Hinweise

Manufactured and sold under exclusive license from Abbott Laboratories.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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D Wirtshafter
Synapse (New York, N.Y.), 28(2), 154-159 (1998-02-05)
Systemic injections of the selective, full, D1 agonists A-77636 and SKF-82958 induced pronounced Fos-like immunoreactivity in the islands of Calleja in the olfactory tubercle of intact rats. Fos expression in this region could also be induced by injections of the
Ales Stuchlik et al.
Behavioural brain research, 172(2), 250-255 (2006-06-20)
Central dopamine neurotransmission is implicated in several physiological and pathophysiological neural processes. In the past years, attention was paid to the role of dopaminergic signaling in the cognitive processes. In the present study, we investigate role of dopamine D1 receptors
E Acquas et al.
Journal of neurochemistry, 70(3), 1088-1093 (1998-03-07)
This study examined the effects of different levels of acetylcholinesterase (AChE) inhibition on dopaminergic regulation of striatal acetylcholine (ACh) release as estimated by in vivo brain microdialysis. Systemic administration of d-amphetamine (2 or 10 mg/kg) increased the striatal output of
Allison L Chausmer et al.
Psychopharmacology, 159(2), 145-153 (2002-02-28)
Recent data suggest that dopamine (DA) D1-like receptor full agonists may be potential pharmacotherapeutic agents for treating cocaine abuse. The structurally novel isochroman D1-like agonist, A-77636, has not been well characterized and may prove to be useful as such an
E Acquas et al.
Psychopharmacology, 125(2), 162-167 (1996-05-01)
The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally

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