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Sigma-Aldrich

FITC-CM-Dextran

average mol wt 70,000

Synonym(e):

FITC-CM-Dextran 70, Fluoresceinisothiocyanat-Carboxymethyl–Dextran

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About This Item

UNSPSC-Code:
12352116
NACRES:
NA.32

Konjugat

FITC conjugate

Qualitätsniveau

100

Form

powder or crystals

Mol-Gew.

average mol wt 70,000

Zusammensetzung

carboxymethyl content, 3-7%

Kennzeichnungsgrad

0.001-0.020 mol/mol FITC glucose

Methode(n)

permeability assay: suitable

Fluoreszenz

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

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Allgemeine Beschreibung

FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.

Anwendung

FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS. FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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