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Y0001290

Honokiol

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100

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About This Item

Empirische Formel (Hill-System):
C18H18O2
CAS-Nummer:
35354-74-6
Molekulargewicht:
266.33
MDL-Nummer:
MFCD00016674
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329831346
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

honokiol

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

−20°C

SMILES String

Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

InChIKey

FVYXIJYOAGAUQK-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Honokiol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Piktogramme

CorrosionEnvironment
GHS05,GHS09

Signalwort

Danger

H-Sätze

H318,H411

Gefahreneinstufungen

Aquatic Chronic 2 - Eye Dam. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

Leider sind derzeit keine COAs für dieses Produkt online verfügbar.

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Ankit Kumar et al.
Future medicinal chemistry, 5(7), 809-829 (2013-05-09)
Honokiol (3,5-di-(2-propenyl)-1,1-biphenyl-2,2-diol) is a natural bioactive neolignan isolated from the genus Magnolia. In recent studies, honokiol has been observed to have anti-angiogenic, anticancer, anti-inflammatory, neuroprotective and GABA-modulating properties in vitro and in preclinical models. Honokiol and its analogs target multiple
Wei Tian et al.
Die Pharmazie, 67(10), 811-816 (2012-11-10)
Honokiol is a small-molecule pharmacologically active component which has various medicinal applications. Increasing interest is paid on its multifunctional anti-tumor effects including inducing tumor cell death, anti-angiogenesis, anti-migration and anti-multiple drug resistance. We addressed a brief summary of the anti-tumor
Ying-Jiun Lai et al.
Journal of cellular biochemistry, 115(11), 1888-1899 (2014-06-07)
Honokiol is a small biphenolic compound, which exerts antitumor activities; however, the precise mechanism of honokiol-induced apoptosis in the human colorectal cancer cells remains unclear. Here, we show that survivin and p53 display the opposite role on the regulation of
S Arora et al.
Current molecular medicine, 12(10), 1244-1252 (2012-07-28)
Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,4'-diol) is a bioactive natural product derived from Magnolia spp. Recent studies have demonstrated anti-inflammatory, anti-angiogenic, anti-oxidative and anticancer properties of honokiol in vitro and in preclinical models. Honokiol targets multiple signaling pathways including nuclear factor kappa B (NF-κB)
Haiquan Wang et al.
Neuropharmacology, 86, 9-21 (2014-06-29)
Recently, increasing evidence has shown that cell cycle activation is a key factor of neuronal death and neurological dysfunction after traumatic brain injury (TBI). This study aims to investigate the effects of Honokiol, a cell cycle inhibitor, on attenuating the
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