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H102

Supelco

Haloperidol-Metabolit II

analytical standard

Synonym(e):

(±)-4-(4-Chlorphenyl)-α-(4-fluorphenyl)-4-hydroxy-1-piperidinbutanol, Haloperidol, reduziert

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About This Item

Empirische Formel (Hill-System):
C21H25ClFNO2
CAS-Nummer:
34104-67-1
Molekulargewicht:
377.88
MDL-Nummer:
MFCD00055102
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329815151
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Farbe

white

Löslichkeit

DMSO: 10 mg/mL

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

SMILES String

OC(CCCN1CCC(O)(CC1)c2ccc(Cl)cc2)c3ccc(F)cc3

InChI

1S/C21H25ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,20,25-26H,1-2,11-15H2

InChIKey

WNZBBTJFOIOEMP-UHFFFAOYSA-N

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000361578
0000361578
FN09271904
027M4605V
078K4619

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J M Leroux et al.
Progress in neuro-psychopharmacology & biological psychiatry, 18(2), 347-353 (1994-03-01)
1. The authors attempted to correlate plasma concentrations in H/rH and clinical efficacy from 8 schizophrenic patients (DSM IIIR) on H. 2. No significant correlations were found between H, rH plasma levels and positive and negative subscale for each patient.
S Ulrich et al.
International clinical psychopharmacology, 14(4), 219-228 (1999-09-01)
The aim of this study was to investigate the effect of reduced haloperidol, the main metabolite of the antipsychotic drug haloperidol, on psychopathology improvement and extrapyramidal adverse effects in acute schizophrenia. The steady-state pharmacokinetics of reduced haloperidol was studied. Serum
J G Shin et al.
British journal of clinical pharmacology, 51(1), 45-52 (2001-02-13)
We evaluated the inhibitory effect of haloperidol and its metabolites on CYP2D6 activity in order to better understand the potential role of these metabolites in drug interactions involving haloperidol. The inhibitory effects of haloperidol and five of its metabolites on
H Hoja et al.
Journal of chromatography. B, Biomedical sciences and applications, 688(2), 275-280 (1997-01-24)
A sensitive and accurate liquid chromatographic-electrospray mass spectrometric (LC-ES-MS) method for the determination of haloperidol (H) and reduced haloperidol (RH) in human plasma is presented, using chlorohaloperidol as the internal standard. A 2-ml volume of plasma was subjected to basic
K Mihara et al.
Therapeutic drug monitoring, 22(3), 245-249 (2000-06-13)
The effect of a genetic polymorphism of inducibility of cytochrome P450 (CYP) 1A2 on the steady state plasma concentrations (Css) of haloperidol and reduced haloperidol was studied to clarify if these Css are dependent on the CYP1A2 activity. The subjects
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