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A115

Supelco

Amitriptylin-Metabolit, (±)-E-10-hydroxyliert-

analytical standard

Synonym(e):

(±)-(E)-5-[3-(Dimethylamino)-propyliden]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

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About This Item

Empirische Formel (Hill-System):
C20H23NO
CAS-Nummer:
64520-05-4
Molekulargewicht:
293.40
MDL-Nummer:
MFCD00069200
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329770681
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

200

Form

solid

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Farbe

white

mp (Schmelzpunkt)

97-99 °C

Löslichkeit

0.1 M HCl: soluble
H2O: insoluble
methanol: soluble

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

SMILES String

CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13

InChI

1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+

InChIKey

GHWBJXOKAFHZAI-SFQUDFHCSA-N

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Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

Metabolit von Amitriptylin, tricyclisches Antidepressivum; Chromatographie-Standard.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
FN10182301
FN06022219
FN04232005
FN04301906
FN12191701

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Die Dokumentenbibliothek aufrufen

R T Coutts et al.
Xenobiotica; the fate of foreign compounds in biological systems, 27(1), 33-47 (1997-01-01)
1. Expressed human cytochrome P450 enzyme CPY2D6 was used to metabolize amitriptyline (AMI). It was established that CYP2D6 not only catalyzed ring 10-hydroxylation of AMI, but also mediated its N-demethylation to nortriptyline (NT), as well as the formation of 10-hydroxy-NT
K Shimoda et al.
Journal of clinical psychopharmacology, 15(3), 175-181 (1995-06-01)
We measured the concentrations in plasma of amitriptyline and its metabolites, nortriptyline and geometric isomers of 10-hydroxynortriptyline and 10-hydroxyamitriptyline, in 73 Japanese psychiatric patients receiving amitriptyline hydrochloride (Tryptanol; Banyu Pharmaceutical Co. Ltd., Tokyo, Japan) by high-performance liquid chromatography. Although there
X H Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 28(2), 85-91 (1993-01-01)
The demethylation and hydroxylation of amitriptyline were calculated from the ratios between the area under concentration--time curve (AUC) of amitriptyline and its three metabolites in eight healthy Chinese volunteers after a single oral dose of 100 mg amitriptyline. Great interindividual
F Coudoré et al.
Cell biology and toxicology, 13(2), 131-137 (1997-02-01)
Biotransformation of amitriptyline (AMI) was studied at different intervals in freshly isolated hepatocytes from healthy or streptozocin-induced diabetic rats in order to investigate the influence of the diabetic state. Levels of free and conjugated AMI, demethylated and hydroxylated metabolites, were
B Mellström et al.
Drug metabolism and disposition: the biological fate of chemicals, 9(6), 565-568 (1981-11-01)
The rates of demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline by microsomes from adult human livers were determined by use of mass-fragmentographic or liquid-chromatographic quantitation of the formed metabolites. The demethylation rates of amitriptyline and 10-hydroxyamitriptyline were higher than
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