MABN481

Anti-Lipocalin-2 Antibody, clone PA348-26.3.5

clone PA348-26.3.5, from mouse

• Synonym(e): ngal, neutrophil lipocalin, siderocalin, Neutrophil gelatinase-associated lipocalin, NGAL, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: PA348-26.3.5, monoclonal
• Speziesreaktivität: human
• Methode(n): ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_005555.1
• UniProt-Hinterlegungsnummer: P80188
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... LCN2(3934)

Beschreibung

Allgemeine Beschreibung

Lipocalin-2 (LCN2) (also known as Neurophil Gelatinase-Associated Lipocalin or NGAL) belongs to a superfamily of lipocalins, a collection of small, diversely functional, extracellular proteins. Lipocalin-2 is secreted from neutrophil granules in three different forms: a monomer of 25 kDa, a disulfide-linked homodimer at 46 kDa, and a disulfide-linked heterodimer with MMP-9 at 135-kDa. It is widely known to induce development of kidney epithelia, to bind and traffic iron, and to act as a molecular signal under inflammatory conditions, such as Crohn’s Disease. Multiple carcinoma studies have also shown elevated expression levels of Lipocalin-2 in several different human tumors affecting such organs as colon, lung, breast, ovaries, and pancreas. Additionally, there has been great interest in this protein as a possible marker for onset of Acute Kidney Injury following cardiac surgery, the progression of Chronic Kidney Disease (CKD), and the survival chances of patients with Chronic Heart Failure (CHF).

Immunogen

Recombinant protein corresponding to human Lipocalin-2.

Anwendung

Research Category
Neurowissenschaft

Research Sub Category
Neurodegenerative Krankheiten

Detect Lipocalin using this mouse monoclonal antibody, Anti-Lipocalin-2 Antibody, clone PA348-26.3.5 validated for use in western blotting, IHC & ELISA.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Lipoacalin-2 in human bone marrow and stomach tissue lysate.

ELISA Analysis: A representative lot from an independent laboratory detected Lipocalin-2 in indirect ELISA.

Qualität

Evaluated by Western Blotting in human lung tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Lipocalin-2 in 10 µg of human lung tissue lysate.

Zielbeschreibung

~23 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable