MABC94
Anti-Sphingosine 1-phosphate receptor 1 (S1P1) Antibody, clone 8B7.1
clone 8B7.1, from mouse
Synonym(e):
Sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1, CD363
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Alle Fotos(3)
About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Antikörperform
purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
8B7.1, monoclonal
Speziesreaktivität
mouse, human, rat
Methode(n)
immunohistochemistry: suitable
western blot: suitable
Isotyp
IgG2a
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... S1PR1(1901)
Allgemeine Beschreibung
Sphingosine 1-phosphate receptor 1(S1PR1 or S1P1), otherwise known as EDG1, is a G-protein coupled receptor which is activated by lysosphingolipid sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA). It is coupled to Gi-protein and MAP kinase signaling pathways, and may cooperate with other S1P receptors to regulate various cellular processes such as differentiation, actin remodeling, and migration. S1P1 is expressed in epithelial cells, fibroblasts, melanocytes, and smooth muscle cells.
Immunogen
GST-tagged recombinant protein corresponding to mouse Sphingosine 1-phosphate receptor 1 (S1P1).
Anwendung
Research Category
Apoptose & Krebs
Apoptose & Krebs
Research Sub Category
GPCR-, cAMP/cGMP- & kalziumabhängige Signalübertragung
GPCR-, cAMP/cGMP- & kalziumabhängige Signalübertragung
This Anti-Sphingosine 1-phosphate receptor 1 (S1P1) Antibody, clone 8B7.1 is validated for use in Western Blotting, IHC for the detection of Sphingosine 1-phosphate receptor 1 (S1P1).
Western Blot Analysis: A 1:500 dilution from a representative lot detected Sphingosine 1-phosphate receptor 1 (S1P1) in human brain tissue lysate.
Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Sphingosine 1-phosphate receptor 1 (S1P1) in rat choroid plexus tissue.
Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Sphingosine 1-phosphate receptor 1 (S1P1) in rat choroid plexus tissue.
Qualität
Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: A 1:1,000 diluiton of this antibody detected Sphingosine 1-phosphate receptor 1 (S1P1) in 10 µg of mouse brain tissue lysate.
Western Blot Analysis: A 1:1,000 diluiton of this antibody detected Sphingosine 1-phosphate receptor 1 (S1P1) in 10 µg of mouse brain tissue lysate.
Zielbeschreibung
~40 kDa observed
Physikalische Form
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2a supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Lagerung und Haltbarkeit
Stable for 1 year at 2-8°C from date of receipt.
Hinweis zur Analyse
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Alhaji H Janneh et al.
Cell reports, 41(10), 111742-111742 (2022-12-09)
Crosstalk between metabolic and signaling events that induce tumor metastasis remains elusive. Here, we determine how oncogenic sphingosine 1-phosphate (S1P) metabolism induces intracellular C3 complement activation to enhance migration/metastasis. We demonstrate that increased S1P metabolism activates C3 complement processing through
Gustavo H Oliveira-Paula et al.
Science advances, 10(11), eadg9278-eadg9278 (2024-03-13)
Canonical Wnt and sphingosine-1-phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β-catenin-S1P cross-talk. In the vascular
Jeffrey Thompson et al.
Aging and disease (2024-06-25)
Endothelial dysfunction and blood-brain barrier (BBB) leakage have been suggested as a fundamental role in the development of cerebral small vessel disease (SVD) pathology. However, the molecular and cellular mechanisms that link cerebral hypoxic hypoperfusion and BBB disruption remain elusive.
Sandeep K Singh et al.
Glia, 70(4), 712-727 (2021-12-28)
Astrocytes, the most abundant glial cells in the mammalian brain, directly associate with and regulate neuronal processes and synapses and are important regulators of brain development. Yet little is known of the molecular mechanisms that control the establishment of astrocyte
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