ABT13
Anti-Sarcolipin Antibody
from rabbit, purified by affinity chromatography
Synonym(e):
Sarcopolin
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Aufgereinigt durch
affinity chromatography
Speziesreaktivität
rabbit
Speziesreaktivität (Voraussage durch Homologie)
rat (based on 100% sequence homology), human (immunogen homology), mouse (based on 100% sequence homology)
Methode(n)
western blot: suitable
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... SLN(6588)
Allgemeine Beschreibung
Sarcolipin (SLN) is a multidomain protein containing lumenal, cytoplasmic, and transmembrane domains. It is found in the membrane of the sarcoplasmic/endoplasmic reticulum of cardiac cells, and is involved in maintaining calcium homestasis underlying muscle contractility in the heart. Sarcoplipin achieves these effects through its regulation of the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a), a calcium transport protein that actively pumps calcium from the cytoplasm into the sarcoplasmic reticulum, resulting in relaxation of the heart muscles. Sarcolipin may also interact with phospholamban, and may contribute to heart failure.
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human Sarcolipin.
Anwendung
Research Category
Zellstruktur
Zellstruktur
Research Sub Category
Cytoskelett
Cytoskelett
Detect Sarcolipin using this Anti-Sarcolipin Antibody validated for use in Western Blotting.
Qualität
Evaluated by Western Blot in rabbit quadraceps tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Sacolipin in rabbit quadraceps tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Sacolipin in rabbit quadraceps tissue lysate.
Zielbeschreibung
~6 kDa observed. An uncharacterized band may be observed at ~13 kDa in some tissue lysates.
Physikalische Form
Affinity purified
Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Lagerung und Haltbarkeit
Stable for 1 year at 2-8°C from date of receipt.
Hinweis zur Analyse
Control
Rabbit quadraceps tissue
Rabbit quadraceps tissue
Sonstige Hinweise
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Joseph M Autry et al.
Veterinary sciences, 7(4) (2020-11-19)
Ca2+ regulation in equine muscle is important for horse performance, yet little is known about this species-specific regulation. We reported recently that horse encode unique gene and protein sequences for the sarcoplasmic reticulum (SR) Ca2+-transporting ATPase (SERCA) and the regulatory
David Morales-Alamo et al.
Scandinavian journal of medicine & science in sports, 30(3), 408-420 (2019-11-02)
Sarcolipin (SLN) is a SERCA uncoupling protein associated with exercise performance and lower adiposity in mice. To determine SLN protein expression in human skeletal muscle and its relationship with adiposity, resting energy expenditure (REE), and performance, SLN was assessed by
Victoria L Wyckelsma et al.
American journal of human genetics, 108(3), 446-457 (2021-02-19)
The protein α-actinin-3 expressed in fast-twitch skeletal muscle fiber is absent in 1.5 billion people worldwide due to homozygosity for a nonsense polymorphism in ACTN3 (R577X). The prevalence of the 577X allele increased as modern humans moved to colder climates
John Butler et al.
Archives of biochemistry and biophysics, 569, 26-31 (2015-02-11)
Studies in sarcolipin knockout mice have led to the suggestion that skeletal muscle sarcolipin plays a role in thermogenesis. The mechanism proposed is uncoupling of the sarcoplasmic reticulum calcium pump. However, in other work sarcolipin was not detected in mouse
Jessica L Braun et al.
International journal of molecular sciences, 22(21) (2021-11-14)
It is well established that microgravity exposure causes significant muscle weakness and atrophy via muscle unloading. On Earth, muscle unloading leads to a disproportionate loss in muscle force and size with the loss in muscle force occurring at a faster
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