5.04841

5,7-Dichlorokynurenic Acid, Sodium Salt

• Synonym(e): 5,7-Dichlorokynurenic Acid, Sodium Salt, 5,7-Dichloro-4-hydroxyquinoline-2-c-arboxylic acid sodium salt, DCKA
• Empirische Formel (Hill-System): C₁₀H₄Cl₂NNaO₃
• CAS-Nummer: 1184986-70-6
• Molekulargewicht: 280.04
• MDL-Nummer: MFCD00674925
• UNSPSC-Code: 12352106
• NACRES: NA.77

Eigenschaften

• Assay: ≥99% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: 79 nM K_i
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: water: 10 mM; 1 M NaOH: 100 mM
• Lagertemp.: 2-8°C
• SMILES String: [Na+].Clc1c2c(nc(cc2O)C(=O)[O-])cc(c1)Cl
• InChI: 1S/C10H5Cl2NO3.Na/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14;/h1-3H,(H,13,14)(H,15,16);/q;+1/p-1
• InChIKey: VPRPMJHKWHCUFW-UHFFFAOYSA-M

Beschreibung

Allgemeine Beschreibung

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (K_i = 79 nM vs. [3H]-glycine).

Biochem./physiol. Wirkung

Primary Target
NMDA receptors

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Baron, B., et al. 1991. Eur. J. Pharmacol.206, 149.
Baron, B., et al. 1990. Mol. Pharmacol.38, 554.
Mugnaini, M., et al. 1998. J. Recept. Signal Transduct. Res.18, 91.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable