Direkt zum Inhalt
Merck

444968

Sigma-Aldrich

PD0325901

≥95% (HPLC), liquid, MEK1/2 inhibitor, Calbiochem®

Synonym(e):

InSolution MEK1/2-Inhibitor III, PD0325901, PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamid, PD325901

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About This Item

Empirische Formel (Hill-System):
C16H14F3IN2O4
CAS-Nummer:
Molekulargewicht:
482.19
MDL-Nummer:
UNSPSC-Code:
12352200
NACRES:
NA.77

Produktbezeichnung

MEK1/2-Inhibitor III, PD0325901, InSolution, ≥95%

Qualitätsniveau

Assay

≥95% (HPLC)

Form

liquid

Hersteller/Markenname

Calbiochem®

Lagerbedingungen

OK to freeze
desiccated (hygroscopic)
protect from light

Versandbedingung

ambient

Lagertemp.

−20°C

SMILES String

Ic1cc(c(cc1)Nc2c(c(ccc2C(=O)NOC[C@H](O)CO)F)F)F

InChI

1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1

InChIKey

SUDAHWBOROXANE-SECBINFHSA-N

Verpackung

Verpackt unter inertem Gas

Warnhinweis

Toxizität: Zulassungsprüfung (Z)

Physikalische Form

Eine 50-mM-Lösung (5 mg/207 µ;l) von MEK1/2-Inhibitor III, PD0325901 (Katalognr. 444966<;/A>;) in DMSO.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

188.6 °F - closed cup - (refers to pure substance)

Flammpunkt (°C)

87 °C - closed cup - (refers to pure substance)


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

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Extracellular signal-regulated kinase (Erk) signaling dynamics elicit distinct cellular responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore the role of Erk signaling dynamics in vivo, as a gradient of activated diphosphorylated Erk (P-Erk)
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Andrew D Economou et al.
Developmental cell, 57(23), 2604-2622 (2022-12-07)
Specification of the germ layers by Nodal signaling has long been regarded as an archetype of how graded morphogens induce different cell fates. However, this deterministic model cannot explain why only a subset of cells at the early zebrafish embryo

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