324385

Doxycycline, Hyclate

A commonly-used broad-spectrum antibiotic.

• Synonym(e): Doxycycline, Hyclate, α-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate
• Empirische Formel (Hill-System): C₂₂H₂₄N₂O₈ · 0.5H₂O · 0.5C₂H₆O · xHCl
• CAS-Nummer: 24390-14-5
• Molekulargewicht: 476.48 (free base basis)
• MDL-Nummer: MFCD07357237
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: crystalline solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Farbe: yellow to yellow-green
• Löslichkeit: water: 50 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;3H,2H2,1H3;2*1H;1H2/b2*21-13+;;;;/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
• InChIKey: QDDHZFKCHWYXJF-PCLMCNLLSA-N

Beschreibung

Allgemeine Beschreibung

A commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC₅₀ = 30 µM) relative to MMP-1 (collagenase-1; IC₅₀ = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC₅₀ = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

A commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC₅₀ = 30 µM) relative to MMP-1 (interstitial collagenase; IC₅₀ = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC₅₀ = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
MMP-8

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate

Warnhinweis

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Rekonstituierung

Follwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.

Sonstige Hinweise

D’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci.732, 112.
Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother.36, 227.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335,H361fd,H412
• P-Sätze: P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable