17-610
Magna ChIP® A - Chromatin-Immunpräzipitations-Kit
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packaging
kit of 22 assay(s)
Quality Level
manufacturer/tradename
Magna ChIP®
technique(s)
immunoprecipitation (IP): suitable
General description
Application
Features and Benefits
- Schneller: Magnetische Protein-A-Beads ermöglichen die Durchführung des gesamten ChIP-Protokolls an nur einem Tag. Alle Reagenzien zum Verarbeiten Ihrer Proben sind enthalten. Sie müssen keine wertvolle Zeit mit ihrer Herstellung vergeuden.
- Einfacher: Spinsäulen erleichtern die DNA-Aufreinigung und machen sie zuverlässiger - keine unordentlichen Phenol-Chloroform-Extraktionen mehr.
Packaging
Preparation Note
Other Notes
- Magnetische Protein-A-Beads
- ChIP-Verdünnungspuffer
- Waschpuffer mit geringem Salzgehalt
- Waschpuffer mit hohem Salzgehalt
- LiCl-Waschpuffer
- TE-Puffer
- Zelllysepuffer
- Zellkernlysepuffer
- ChIP-Elutionspuffer (ohne Proteinase K)
- 10X Glycin
- 10X PBS
- Proteaseinhibitor-Cocktail II
- Proteinase K
- Spinfilter
- Sammelröhrchen
- Bindungsreagens A
- Waschreagens B
- Elutionsreagens C
Legal Information
Disclaimer
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - ED ENV 1 - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
Lagerklasse
3 - Flammable liquids
flash_point_f
55.4 °F
flash_point_c
13 °C
wgk
WGK 3
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Verwandter Inhalt
Cancer is a complex disease manifestation. At its core, it remains a disease of abnormal cellular proliferation and inappropriate gene expression. In the early days, carcinogenesis was viewed simply as resulting from a collection of genetic mutations that altered the gene expression of key oncogenic genes or tumor suppressor genes leading to uncontrolled growth and disease (Virani, S et al 2012). Today, however, research is showing that carcinogenesis results from the successive accumulation of heritable genetic and epigenetic changes. Moreover, the success in how we predict, treat and overcome cancer will likely involve not only understanding the consequences of direct genetic changes that can cause cancer, but also how the epigenetic and environmental changes cause cancer (Johnson C et al 2015; Waldmann T et al 2013). Epigenetics is the study of heritable gene expression as it relates to changes in DNA structure that are not tied to changes in DNA sequence but, instead, are tied to how the nucleic acid material is read or processed via the myriad of protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions that ultimately manifest themselves into a specific expression phenotype (Ngai SC et al 2012, Johnson C et al 2015). This review will discuss some of the principal aspects of epigenetic research and how they relate to our current understanding of carcinogenesis. Because epigenetics affects phenotype and changes in epigenetics are thought to be key to environmental adaptability and thus may in fact be reversed or manipulated, understanding the integration of experimental and epidemiologic science surrounding cancer and its many manifestations should lead to more effective cancer prognostics as well as treatments (Virani S et al 2012).
"Epigenetics describes heritable changes in gene expression caused by non-genetic mechanisms instead of by alterations in DNA sequence. These changes can be cell- or tissue-specific, and can be passed on to multiple generations. Epigenetic regulation enriches DNAbased information, allowing a cell to vary its response across diverse biological and environmental contexts. Although epigenetic mechanisms are primarily centered in the nucleus, these mechanisms can be induced by environmental signals such as hormones, nutrients, stress, and cellular damage, pointing to the involvement of cytoplasmic and extracellular factors in epigenetic regulation."
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 17-610 | 04053252005374 |