14-329-M
JNK2α2/SAPK1a Protein, active, 10 µg
Active, N-terminal His-tagged, full length human JNK2α2/SAPK1a, for use in Kinase Assays.
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About This Item
UNSPSC-Code:
12352202
eCl@ss:
32160405
NACRES:
NA.41
Biologische Quelle
human
Qualitätsniveau
Mol-Gew.
Mw 49.2 kDa
Hersteller/Markenname
Upstate®
Methode(n)
activity assay: suitable (kinase)
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Angaben zum Gen
human ... MAPK9(5601)
Allgemeine Beschreibung
N-terminal His-tagged, full length human JNK2α2/SAPK1a
Product Source: Expressed in Sf21 cells
Biochem./physiol. Wirkung
Protein Target: JNK2α2/SAPK1a
Target Sub-Family: CMGC
Verpackung
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-329M when ordering the 250 µg size.
Qualität
Routinely evaluated by phosphorylation of ATF2 (amino acids 19-96)
Physikalische Form
Ni2+/NTA-agarose
Lagerung und Haltbarkeit
6 months at -70°C
Sonstige Hinweise
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Analysenzertifikate (COA)
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Girish V Putcha et al.
Neuron, 38(6), 899-914 (2003-06-24)
Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM(EL) and HRK, which in turn are critical for BAX-dependent cytochrome c release, caspase activation, and apoptosis. Here, we report that
Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
S P Zhong et al.
The Journal of biological chemistry, 275(28), 20980-20984 (2000-05-12)
Histone H3 is the core protein of the nucleosome. Phosphorylation of H3 involves immediate early gene expression, chromatin remodeling, and chromosome condensation during mitosis. Very recently, Rsk2 or MSK1 kinase-mediated phosphorylation of H3 at serine 10 was reported. In the
S Gupta et al.
The EMBO journal, 15(11), 2760-2770 (1996-06-03)
The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine and tyrosine. Ten JNK isoforms were identified in human brain by molecular cloning. These protein kinases correspond to
S Gupta et al.
Science (New York, N.Y.), 267(5196), 389-393 (1995-01-20)
Treatment of cells with pro-inflammatory cytokines or ultraviolet radiation causes activation of the c-Jun NH2-terminal protein kinase (JNK). Activating transcription factor-2 (ATF2) was found to be a target of the JNK signal transduction pathway. ATF2 was phosphorylated by JNK on
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