14-309
PCAF Protein, Active, 50 µg
PCAF recombinant GST fusion protein, for use in Histone Acetyltransferase Assays. (HAT).
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About This Item
UNSPSC-Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32
Empfohlene Produkte
Rekombinant
expressed in E. coli
Qualitätsniveau
Mol-Gew.
Mw 79 kDa
Hersteller/Markenname
Upstate®
Methode(n)
activity assay: suitable (histone acetyltransferase (HAT))
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Allgemeine Beschreibung
Product Source: expressed in E. Coli corresponding to amino acids 352-832
Qualität
routinely evaluated by acetylation of core histones in vitro
Sonstige Hinweise
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Giosalba Burgio et al.
Journal of enzyme inhibition and medicinal chemistry, 31(sup3), 75-82 (2016-07-09)
Histones and polyamines are important determinants of the chromatin structure. Histones form the core of nucleosome particles and their modification by acetylation of N-terminal tails is involved in chromatin structural changes and transcriptional regulation. Polyamines, including spermidine, are also targets
Matteo Savoia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(3), 4107-4123 (2018-12-12)
The epigenetic enzyme p300/CBP-associated factor (PCAF) belongs to the GCN5-related N-acetyltransferase (GNAT) family together with GCN5. Although its transcriptional and post-translational function is well characterized, little is known about its properties as regulator of cell metabolism. Here, we report the
Prabhat Kumar Purbey et al.
Molecular and cellular biology, 29(5), 1321-1337 (2008-12-24)
Special AT-rich binding protein 1 (SATB1) acts as a global regulator of gene expression by recruiting various corepressor or coactivator complexes, thereby establishing a unique chromatin structure at its genomic targets in a context-dependent manner. Although SATB1 acts predominantly as
R L Schiltz et al.
The Journal of biological chemistry, 274(3), 1189-1192 (1999-01-09)
A number of transcriptional coactivators possess intrinsic histone acetylase activity, providing a direct link between hyperacetylated chromatin and transcriptional activation. We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes. p300 specifically acetylates
Chromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3.
Jae-Hwan Lim,Katherine L West,Yaffa Rubinstein,Michael Bergel,Yuri V Postnikov,Michael Bustin
The Embo Journal null
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