03-0207-00

SMC^® Human PD-1 High Sensitivity Immunoassay Kit

• Synonym(e): PD-1 Single Molecule Counting kit, PD-1 ultra-sensitive immunoassay, PD-1 immunoassay kit, Programmed cell death protein 1 kit, PD-1 kit
• UNSPSC-Code: 12161503
• NACRES: NA.47

Eigenschaften

• Speziesreaktivität: human
• Qualitätsniveau: 200
• Parameter: 50 μL sample volume (diluted 2-fold in standard diluent)
• assay range: intra-assay cv: ≤5%; (n=15); linearity: 80-117%; (Plasma); linearity: 91-135%; (Serum); recovery range: 53-100%; (Plasma); recovery range: 80-109%; (Serum); sensitivity: 1.74 pg/mL; standard curve range: 0.87-3,000 pg/mL; inter-assay cv: ≤14%; (n=15)
• Methode(n): single molecule counting: suitable
• Aufnahme: sample type plasma (K2 EDTA); sample type serum
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

Programmed cell death protein 1 (PD-1), CD279, is a type I membrane protein found in T cells, B cells, and macrophages that binds Programmed cell death ligand 1 and 2 (PD-L1 and PD-L2). PD-1 is found in both soluble and insoluble forms. PD-1 regulates the body’s immune response through a variety of pathways, down-regulating immune system activity and suppressing T-cell inflammatory activity. PD-1 has been implicated as playing a role in cancers, autoimmune diseases, the immune response to viruses, and in immunological pathways related to brain repair. As an immune checkpoint, PD-1 promotes apoptosis of antigen-specific T-cells in lymph nodes and reduces apoptosis in regulatory T-cells. Blockers of the PD-1 pathway have been approved as cancer therapeutics.

Research Category: Cancer
Research Sub-Category: Immuno-Oncology

Spezifität

This assay was tested for cross-reactivity with PD-L1. No cross-reactivity was detected with this analyte.

Anwendung

Used for ultrasensitivite quantification of Human PD-1 in human serum and plasma.

Leistungsmerkmale und Vorteile

This SMC^® kit features:

• Accurate and reproducible performance on the state-of-the-art SMCxPRO^® ultrasensitive immunoassay system.
• Compatiblity with automated liquid handling

Rechtliche Hinweise

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302 + H312 + H332,H319,H360FD,H373,H412
• P-Sätze: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
• Zielorgane: Respiratory Tract
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects