D-915

Desalkylflurazepam -Lösung

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirische Formel (Hill-System): C₁₅H₁₀ClFN₂O
• CAS-Nummer: 2886-65-9
• Molekulargewicht: 288.70
• EG-Nummer: 200-659-6
• MDL-Nummer: MFCD00083443
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Qualitätsniveau: 300
• Form: liquid
• Leistungsmerkmale: Snap-N-Spike^®/Snap-N-Shoot^®
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland)
• Konzentration: 1.0 mg/mL in methanol
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): clinical testing
• Format: single component solution
• Lagertemp.: −20°C
• SMILES String: Fc1ccccc1C2=NCC(=O)Nc3ccc(Cl)cc23
• InChI: 1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
• InChIKey: UVCOILFBWYKHHB-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Desalkylflurazepam, also known as N-desalkyl-2-oxoquazepam, is a long-acting metabolite of the benzodiazepine drug flurazepam. Flurazepam is sold unde the trade names Dalmane and Dalmadorm for the treatment of mild to moderate insomnia. This Certified Spiking Solution^® is suited for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis or urine drug testing.

Anwendung

• Pharmacokinetic profiling: Research on flurazepam metabolites, including Desalkylflurazepam, utilizes high-performance liquid chromatography for detailed pharmacokinetic studies in rats, providing essential data for understanding drug behavior and metabolism (Lau et al., 1987).


• Neuroscience tool: Desalkylflurazepam is applied in neuroscience research to understand the dynamics of benzodiazepine binding on living cells, utilizing small ligands in fluorescence correlation spectroscopy, a method pivotal for real-time molecular interactions study (Hegener et al., 2002).


• Drug testing applications: The compound is used in the development of analytical techniques like ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS/MS) for the detection of benzodiazepines in hair, useful in workplace drug testing and forensic science (Ramírez Fernández et al., 2015).


• Toxicological analysis: Desalkylflurazepam serves as a reference standard in forensic toxicology to facilitate the rapid determination of benzodiazepines and their metabolites in biological samples, crucial for accurate and swift diagnostic purposes (Jeong et al., 2015).


• Immunosorbent assay applications: This benzodiazepine metabolite is instrumental in examining cross-reactivity of psychoactive substances in enzyme-linked immunosorbent assay (ELISA) techniques, enhancing drug testing capabilities in clinical settings (Cieri et al., 2024).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H225,H301 + H311 + H331,H370
• P-Sätze: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Zielorgane: Eyes,Central nervous system
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 2
• Flammpunkt (°F): 49.5 °F - closed cup
• Flammpunkt (°C): 9.7 °C - closed cup