860811P

12:0(2R-OH) Ceramide

Avanti Research^™ - A Croda Brand 860811P, powder

• Synonym(e): N-(2′-(R)-hydroxylauroyl)-D-erythro-sphingosine
• Empirische Formel (Hill-System): C₃₀H₅₉NO₄
• CAS-Nummer: 1246298-44-1
• Molekulargewicht: 497.79
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 5 mg (860811P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860811P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCC)=O)CO

Beschreibung

Allgemeine Beschreibung

Ceramides containing 2-hydroxy fatty acid (hFA) are found primarily in the epidermis. 12:0(2R-OH) Ceramide is a 2R hydroxylated lauric acid-containing ceramide.

Biochem./physiol. Wirkung

Hydroxy fatty acid (hFA)-sphingolipids play a specific role in cell signaling. Synthesis of hFA-ceramides requires fatty acid 2-hydroxylase (FA2H). Mutations of this key enzyme are associated with the development of nervous system disorders such as leukodystrophy and spastic paraparesis in humans. hFA-ceramides are essential for the epidermal permeability barrier function. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.

Verpackung

5 mL Amber Glass Screw Cap Vial (860811P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3