Direkt zum Inhalt
Merck
Alle Fotos(1)

Key Documents

View All Documentation

860657P

Avanti

sphingosine-d7

Avanti Research™ - A Croda Brand 860657P, powder

Synonym(e):

D-erythro-sphingosine-d7

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C18H30D7NO2
CAS-Nummer:
1246304-34-6
Molekulargewicht:
306.54
UNSPSC-Code:
12352211
NACRES:
NA.25

Form

powder

Verpackung

pkg of 1 × 1 mg (860657P-1mg)
pkg of 1 × 5 mg (860657P-5mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 860657P

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

OC[C@@](N)([H])[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

Allgemeine Beschreibung

Sphingosine-d7 is a deuterated derivative of sphingosine. Sphingosine is an important bioactive sphingolipid metabolite. It is a 18-carbon amino alcohol derived from sphingomyelin. Sphingosine contains an unsaturated hydrocarbon chain.

Anwendung

Sphingosine-d7 has been used as an internal standard in liquid chromatography–tandem mass spectrometry for quantitative analysis of sphingolipids in biological samples.

Biochem./physiol. Wirkung

Sphingosine negatively regulates cell proliferation and induces apoptosis. It has an ability to regulate the activities of phospholipases, protein kinases, ion channels, cannabinoid receptor type 1 (CB-1) receptors and steroidogenic factor 1 (SF-1) receptors. Sphingosine acts as a precursor for ceramide synthesis.

Verpackung

5 mL Amber Glass Screw Cap Vial (860657P-1mg)
5 mL Amber Glass Screw Cap Vial (860657P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

auch häufig zusammen mit diesem Produkt gekauft

Produkt-Nr.
Beschreibung
Preisangaben

Lagerklassenschlüssel

11 - Combustible Solids

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Iulia Zoicas et al.
Cells, 9(5) (2020-05-24)
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb)
Stephanie Schwalm et al.
The American journal of pathology, 187(11), 2413-2429 (2017-08-16)
Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring, and loss of kidney function. In this study, we investigated the role of sphingosine kinase-2 (SPHK2) on the progression of tubular fibrosis by
Henning Carstens et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(6), 1015-1028 (2019-12-20)
Pulmonary infections with Pseudomonas aeruginosa (P. aeruginosa) or Staphylococcus aureus (S. aureus) are of utmost clinical relevance in patients with cystic fibrosis, chronic obstructive pulmonary disease, after trauma and burn, upon ventilation or in immuno-compromised patients. Many P. aeruginosa and
the
Lipid Mediators and Their Metabolism in the Brain (2011)
Irina Alecu et al.
Journal of lipid research, 58(1), 60-71 (2016-11-23)
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the inherited neuropathy, hereditary
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.