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Merck

840521P

Avanti

18:1 Lysyl PG

1,2-dioleoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] (chloride salt), powder

Synonym(e):

Lysyl-DOPG

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About This Item

Empirische Formel (Hill-System):
C48H93Cl2N2O11P
CAS-Nummer:
Molekulargewicht:
976.14
UNSPSC-Code:
51191904
NACRES:
NA.25

Assay

>99% (up to 15% acyl migration on lysine, TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (840521P-1mg)
pkg of 1 × 10 mg (840521P-10mg)

Hersteller/Markenname

Avanti Research - A Croda Brand 840521P

Lipid-Typ

phospholipids
bioactive lipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

OC(COC([C@@](CCCC[NH3+])([H])[NH3+])=O)COP(O)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-].[Cl-]

Allgemeine Beschreibung

18:1 Lysyl PG/1,2-dioleoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] (lysyl-DOPG) is a synthetic phospholipid. It has a lysine group, added to the terminal glycerol of DOPG. Lysyl-phosphatidylglycerol (LPG), a membrane lipid is mainly seen in gram-positive bacteria. It is cationic phospholipid.

Anwendung

18:1 Lysyl PG is suitable to prepare liposome solutions.

Biochem./physiol. Wirkung

Lysyl-phosphatidylglycerol (lysyl-PG) in the cytoplasmic membranes of Staphylococcus is associated with improved resistance to antibiotics, like daptomycin and host defense antimicrobial peptides.

Verpackung

5 mL Amber Glass Screw Cap Vial (840521P-1mg)
5 mL Clear Glass Sealed Ampule (840521P-10mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Kunden haben sich ebenfalls angesehen

The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions
Sohlenkamp C, et al.
Molecular plant-microbe interactions : MPMI, 20(11), 1421-1430 (2007)
Lysyl-phosphatidylglycerol attenuates membrane perturbation rather than surface association of the cationic antimicrobial peptide 6W-RP-1 in a model membrane system: implications for daptomycin resistance
Kilelee E, et al.
Antimicrobial Agents and Chemotherapy, 54(10), 4476-4479 (2010)
Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide
Williamson JA, et al.
Journal of molecular biology, 393(2), 383-396 (2009)
Christian Sohlenkamp et al.
Molecular plant-microbe interactions : MPMI, 20(11), 1421-1430 (2007-11-06)
Lysyl-phosphatidylglycerol (LPG) is a well-known membrane lipid in several gram-positive bacteria but is almost unheard of in gram-negative bacteria. In Staphylococcus aureus, the gene product of mprF is responsible for LPG formation. Low pH-inducible genes, termed IpiA, have been identified
Lipid bilayer modules as determinants of K+ channel gating
Syeda R, et al.
Test, 289(7), 4233-4243 (2014)

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