Direkt zum Inhalt
Merck
Alle Fotos(2)

Wichtige Dokumente

Gesamtdokumentation anzeigen

700077P

Avanti

FF-MAS

Avanti Research™ - A Croda Brand

Synonym(e):

14-demethyl-14-dehydrolanosterol, 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol; follicular fluid meiosis-activating sterol

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(2)

About This Item

Empirische Formel (Hill-System):
C29H46O
CAS-Nummer:
64284-64-6
Molekulargewicht:
410.67
MDL-Nummer:
MFCD00945031
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1 × 1 mg (700077P-1mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand

Versandbedingung

dry ice

Lagertemp.

−70°C

SMILES String

O[C@@H]1C([C@H]2[C@](CC1)(C3=C(CC2)C4=CC[C@@H]([C@]4(CC3)C)[C@@H](CCC=C(C)C)C)C)(C)C

InChI

1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1

InChIKey

LFQXEZVYNCBVDO-PBJLWWPKSA-N

Allgemeine Beschreibung

Follicular fluid meiosis-activating sterol (FF-MAS) is an intermediate in the cholesterol biosynthetic pathway present in all cells, and may represent the physiological signal that instructs the oocyte to reinitiate meiosis.

Anwendung

FF-MAS has been used:
  • as a standard in gas chromatography/ mass spectroscopy (GC/MS) for profiling sterols of oligodendrocyte progenitor cells (OPCs)
  • as Dulbecco′s modified eagle medium (DMEM) medium supplement to test its effect on cancer cell viability
  • to evaluate its effect on LXRβ-overexpressing squamous carcinoma SCC61 cells

Biochem./physiol. Wirkung

14-demethyl-14-dehydrolanosterol (FF-MAS) was first identified in follicular fluid of women and plays a key role in oocyte nuclear maturation. The levels of FF-MAS may be regulated by cytochrome P450 family 27 subfamily A member 1. Supplementation of FF-MAS to oocytes promotes meiotic maturation favoring preimplantation. However, FF-MAS has low solubility and is metabolized to cholesterol rapidly.

Verpackung

5 mL Amber Glass Screw Cap Vial (700077P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

Leider sind derzeit keine COAs für dieses Produkt online verfügbar.

Wenn Sie Hilfe benötigen, wenden Sie sich bitte an Kundensupport

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

A synthetic analogue of meiosis-activating sterol (FF-MAS) is a potent agonist promoting meiotic maturation and preimplantation development of mouse oocytes maturing in vitro
MarinB, et al.
Human Reproduction, 19(10), 2340-2344 (2004)
Robert J Fakheri et al.
Steroids, 76(3), 211-215 (2010-10-19)
Autoregulation of cholesterol synthesis focuses on the 19 metabolic steps from lanosterol to cholesterol. Although synchronization of their rates of synthesis in all tissues was the paradigm, a known exception occurs in the ovary where a local increase in a
Autoregulation of cholesterol synthesis: Physiologic and pathophysiologic consequences
Fakheri RJ and Javitt NB
Steroids, 76(3), 211-215 (2011)
Two syntheses of FF-MAS
Blume T, et al.
Organic Letters, 5(11), 1837-1839 (2003)
Endogenous sterol metabolites regulate growth of EGFR/KRAS-dependent tumors via LXR
Gabitova L, et al.
Cell Reports, 12(11), 1927-1938 (2015)
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.