QBD10867

SPDP-dPEG^®₃₆-NHS ester

>95% (HPLC)

• Synonym(e): OPSS-PEG₁₅₀₀-NHS ester, OPSS-PEG₃₆-NHS ester, SPDP-PEG-NHS ester, SPDP-PEG₃₆-NHS ester
• Empirische Formel (Hill-System): C₈₇H₁₆₁N₃O₄₁S₂
• Molekulargewicht: 1969.33
• MDL-Nummer: MFCD21363283
• UNSPSC-Code: 12352108
• NACRES: NA.22

Eigenschaften

• Assay: >95% (HPLC)
• Form: solid or viscous liquid
• Eignung der Reaktion: reaction type: Pegylations
• Polymerarchitektur: shape: linear; functionality: heterobifunctional
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Leistungsmerkmale und Vorteile

SPDP-dPEG₃₆-NHS ester is an amphiphilic, water-soluble PEGylation reagent that is designed to crosslink amines and free thiols. SPDP (also referred to as orthopyridyl disulfide, or OPSS) reacts with sulfhydryl groups to form disulfide bonds. The N-hydroxysuccinimidyl (NHS) ester reacts with free amines to form amide bonds. The single molecular weight, discrete chain length polyethylene glycol (dPEG) chain is 115 atoms (137.8 Å) long. SPDP-dPEG36-NHS ester is used like SPDP and its related hydrophobic products. However, the water-soluble dPEG product prevents hydrophobicity-triggered precipitation of compounds to which it is conjugated. SPDP-dPEG₃₆-NHS ester is a monodisperse equivalent of the polymeric PEG₁₅₀₀.

Rechtliche Hinweise

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable