D2388

Dimethyl-3,3′-Dithiopropionimidat -dihydrochlorid

powder

• Synonym(e): DTBP, Dimethyl-3,3′-dithiodipropionimidat -dihydrochlorid, Wang-Richards’ Reagens -dihydrochlorid
• Empirische Formel (Hill-System): C₈H₁₆N₂O₂S₂ · 2HCl
• CAS-Nummer: 38285-78-8
• Molekulargewicht: 309.28
• NACRES: NA.22
• PubChem Substance ID: 57654084
• UNSPSC Code: 12352116
• MDL number: MFCD00043245
• Form: powder

Eigenschaften

• form: powder
• reaction suitability: reagent type: cross-linking reagent
• solubility: H₂O: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.Cl.COC(=N)CCSSCCC(=N)OC
• InChI: 1S/C8H16N2O2S2.2ClH/c1-11-7(9)3-5-13-14-6-4-8(10)12-2;;/h9-10H,3-6H2,1-2H3;2*1H
• InChI key: CQBCVFHLZAVNPF-UHFFFAOYSA-N

Beschreibung

Application

A homobifunctional, cleavable cross-linking reagent. Typically, reacted with primary amines in the pH range 7.0-10.0 to form amidine bonds.

Reactant for:

• Synthesis of glutathione-sensitive cross-linked polyethylenimine gene vector
• Preparation of cyclodextrin-containing polymers designed for gene delivery
• Crosslinking of chick oviduct progesterone-receptor subunits

Other Notes

Note that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker.

Disclaimer

The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315
• Hazard Classifications: Skin Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves