924091

Alkyne-a-TCO

• Synonym(e): (R,E)-1-(2-(Prop-2-yn-1-yloxy)ethyl)cyclooct-4-en-1-ol, 5-ax-Hydroxy-5-eq-(2-(prop-2-yn-1-yloxy)ethyl)-trans-cyclooctene, Clickable axial 5-hydroxy-trans-cyclooctene
• Empirische Formel (Hill-System): C₁₃H₂₀O₂
• Molekulargewicht: 208.30

Eigenschaften

• Eignung der Reaktion: reagent type: chemical modification reagent; reagent type: cross-linking reagent; reaction type: click chemistry
• Qualitätsniveau: 100
• Funktionelle Gruppe: (Alkyne)
• Lagertemp.: −20°C

Beschreibung

Anwendung

Alkyne-a-TCO is an axial trans-cyclooctene (a-TCO) for bioconjugation and protein labeling. Alkyne-a-TCO has a CuAAC clickable tag, and the a-TCO reacts rapidly with tetrazines through Diels-Alder reactions, a type of bioorthogonal, copper-free click chemistry. As demonstrated by the Joe Fox lab in Pigga, et al, a-TCOs are more reactive and hydrophilic than standard TCOs, providing favorable physiochemical properties for live-cell and in vivo labeling.

Other new a-TCOs:

• NHS ester-a-TCO (924075)
• TAMRA-a-TCO (924083)
• Alkyne-a-TCO (924091)
• Amine-a-TCO (924113)

Sonstige Hinweise

General, Divergent Platform for Diastereoselective Synthesis of trans-Cyclooctenes with High Reactivity and Favorable Physiochemical Properties

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable