909610

BMSO crosslinker

≥95%

• Synonym(e): 3,3′-Sulfinylbis(N-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)propanamide), Mass spectrometry-cleavable crosslinker for studying protein-protein interations
• Empirische Formel (Hill-System): C₁₈H₂₂N₄O₇S
• CAS-Nummer: 2231640-10-9
• Molekulargewicht: 438.45
• MDL-Nummer: MFCD32857253
• UNSPSC-Code: 12352200
• NACRES: NA.22

Eigenschaften

• Assay: ≥95%
• Form: powder
• Lagertemp.: 2-8°C
• SMILES String: [S](=O)(CCC(=O)NCCN2C(=O)C=CC2=O)CCC(=O)NCCN1C(=O)C=CC1=O
• InChIKey: PUNDHDZIOGBGHG-UHFFFAOYSA-N

Beschreibung

Anwendung

BMSO (bismaleimide sulfoxide) crosslinker is a homobifunctional, cysteine residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). BMSO possesses two maleimide reactive groups for targeting Cys, a 24.2 Å spacer arm, and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. While similar reagents react with lysine (Lys) and acidic residues, targeting Cys provides further opportunity to characterize protein interaction surfaces. Additionally, the post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS.

BMSO crosslinker provides complementary data to amine-reactive and acidic residue-targeting reagents and will find wide utility in the elucidation of PPIs, study of proteins that function as complexes, quantification of structural dynamics, and the quest for targeting "undruggable" protein targets.

Sonstige Hinweise

Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein Interactions

Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein–Protein Interactions

Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling

Rechtliche Hinweise

Subject to US provisional patent application #62/845,240 of the Regents of the University of California

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable