773069

Fmoc-N-Me-Cys(Trt)-OH

97% (HPLC)

• Synonym(e): N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine
• Empirische Formel (Hill-System): C₃₈H₃₃NO₄S
• CAS-Nummer: 944797-51-7
• Molekulargewicht: 599.74
• UNSPSC-Code: 12352209
• NACRES: NA.26

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97% (HPLC)
• Form: powder or crystals
• Optische Aktivität: [α]22/D -25.0°, c = 0.5% in dichloromethane
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• mp (Schmelzpunkt): 234-239 °C
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: Fmoc
• Lagertemp.: 2-8°C
• InChI: 1S/C38H33NO4S/c1-39(37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34)35(36(40)41)26-44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29/h2-24,34-35H,25-26H2,1H3,(H,40,41)/t35-/m0/s1
• InChIKey: RAKOPMQMPUNRGI-DHUJRADRSA-N

Beschreibung

Anwendung

Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).
It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable