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Gold nanoparticles
15 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Synonym(e):
Gold nanoparticles NH2 functionalized, Au NP NH2, Gold Colloid
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About This Item
Empfohlene Produkte
Materialien
PEG 5000
Qualitätsniveau
Form
dispersion in H2O
nanoparticles
Verpackung
poly bottle of 1 mL
OD
50
Durchmesser
15 nm
pH-Wert
6.0-8.0 (25 °C)
Löslichkeit
water: miscible
Dichte
1.00 g/cm3
λmax
520 nm
Funktionelle Gruppe
amine
Lagertemp.
2-8°C
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Allgemeine Beschreibung
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.††††
Anwendung
Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.
Leistungsmerkmale und Vorteile
- A negatively charged siRNA-PEG complex, attached to positively charged GNPs, is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
- The PEG coating, decreases the cytotoxicity and increases efficiency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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The aim of the present study was developing a surface plasmon resonance (SPR) nanosensor to detect Escherichia coli (E. coli) for the diagnosis of urinary tract infections by using surface imprinted Au nanoparticles (AuNPs) as a recognition element. In order
Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin.
Journal of the American Chemical Society, 132(13), 4678-4684 (2010-03-17)
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of
Langmuir : the ACS journal of surfaces and colloids, 21(20), 9303-9307 (2005-09-21)
The interaction of bovine serum albumin (BSA) with gold colloids and surfaces was studied using zeta-potential and quartz crystal microbalance (QCM) measurements, respectively, to determine the surface charge and coverage. The combination of these two measurements suggests that BSA binding
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
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