513210

(S)-(−)-2-Methyl-2-propansulfinamid

97%

• Synonym(e): (S)-(-)-tert-Butanesulfinamide, (S)-(-)-tert-Butyl sulfinamide, (S)-2-Methyl-2-propanesulfinamide, (S)-tert-Butanesulfinamide, (S)-tert-Butylsulfinamide
• Lineare Formel: (CH₃)₃CS(O)NH₂
• CAS-Nummer: 343338-28-3
• Molekulargewicht: 121.20
• MDL-Nummer: MFCD05861480
• UNSPSC-Code: 12352111
• PubChem Substanz-ID: 24873681
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97%
• Optische Aktivität: [α]20/D −4.5°, c = 1 in chloroform
• mp (Schmelzpunkt): 97-101 °C (lit.)
• Lagertemp.: 2-8°C
• SMILES String: CC(C)(C)S(N)=O
• InChI: 1S/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3/t7-/m0/s1
• InChIKey: CESUXLKAADQNTB-ZETCQYMHSA-N

Beschreibung

Anwendung

Can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins.

Chiral auxiliary used in an asymmetric preparation of trifluoroethylamines by conversion of trifluoroacetaldehyde to a chiral imine followed by treatment with an aryl lithium and acidic methanolysis.

Useful reagent for synthesizing chiral amines.

Ellman′s Sulfinamides

(S)-(-)-2-Methyl-2-propanesulfinamide may be used to develop benzofuran-based farnesyltransferase inhibitors as anti-cancer agents. It may also be used to prepare (20E)-N-[t-butyl-(S)-sulfinyl]-3β-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the preparation of androgen receptor antagonists.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)