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299154

Sigma-Aldrich

L-Methionin-(methyl-13C, d3)

≥99 atom % 13C, ≥99 atom % D, ≥99% (CP)

Synonym(e):

SILAC Aminosäure, L-Methionin-Methyl-13C,Methyl-d3

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About This Item

Lineare Formel:
13CD3SCH2CH2CH(NH2)CO2H
CAS-Nummer:
73488-65-0
Molekulargewicht:
153.22
MDL-Nummer:
MFCD00002624
UNSPSC-Code:
12352209
PubChem Substanz-ID:
24858018
NACRES:
NA.12

Isotopenreinheit

≥99 atom % 13C
≥99 atom % D

Qualitätsniveau

200

Assay

≥99% (CP)

Form

powder

Optische Aktivität

[α]25/D +23.1°, c = 1 in 1 M HCl

Methode(n)

protein expression: suitable

mp (Schmelzpunkt)

284 °C (dec.) (lit.)

Massenverschiebung

M+4

SMILES String

[2H][13C]([2H])([2H])SCC[C@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1+1D3

InChIKey

FFEARJCKVFRZRR-ZIHWZSJBSA-N

Anwendung

Used in the methodology of stable isotope tagging of epitopes (SITE) for identification of virus-induced peptides in vaccine development.

Verpackung

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MBBD6588
MBBC8825
MBBC7127
MBBC5577
MBBB5339V

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Martin Bachman et al.
Nature chemical biology, 11(8), 555-557 (2015-06-23)
5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable
Hugo D Meiring et al.
Molecular & cellular proteomics : MCP, 5(5), 902-913 (2006-01-25)
Identification of peptides presented in major histocompatibility complex (MHC) class I molecules after viral infection is of strategic importance for vaccine development. Until recently, mass spectrometric identification of virus-induced peptides was based on comparative analysis of peptide pools isolated from
Valeria Spadotto et al.
Nucleic acids research, 48(1), 96-115 (2019-11-30)
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Microprocessor and its associated proteins. Through high resolution mass spectrometry (MS)- proteomics we discovered that this complex is extensively methylated, with 84
Daniele Musiani et al.
Science signaling, 12(575) (2019-04-04)
Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the involvement of PRMT5, the major type II PRMT, in cell survival and differentiation pathways that are important during development and in tumorigenesis. PRMT5
Daniele Musiani et al.
Cell reports, 30(4), 1208-1222 (2020-01-30)
Protein arginine methyltransferase 1 (PRMT1) is overexpressed in various human cancers and linked to poor response to chemotherapy. Various PRMT1 inhibitors are currently under development; yet, we do not fully understand the mechanisms underpinning PRMT1 involvement in tumorigenesis and chemoresistance.
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