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U3385

Sigma-Aldrich

UA62784

≥98% (HPLC)

Synonym(s):

4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one

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About This Item

Empirical Formula (Hill Notation):
C23H15NO3
CAS Number:
313367-92-9
Molecular Weight:
353.37
MDL number:
MFCD00489199
UNSPSC Code:
12352202
PubChem Substance ID:
329827627
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >2 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34

InChI

1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3

InChI key

SVICLWPFAQYZLX-UHFFFAOYSA-N

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Biochem/physiol Actions

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

Preparation Note

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sergey Tcherniuk et al.
Chemistry & biology, 18(5), 631-641 (2011-05-26)
A recent screen for compounds that selectively targeted pancreatic cancer cells isolated UA62784. We found that UA62784 inhibits microtubule polymerization in vitro. UA62784 interacts with tubulin dimers ten times more potently than colchicine, vinblastine, or nocodazole. Competition experiments revealed that UA62784
Julia Würtemberger et al.
PloS one, 15(9), e0238572-e0238572 (2020-09-09)
Functional genomic screening of KRAS-driven mouse sarcomas was previously employed to identify proliferation-relevant genes. Genes identified included Ubiquitin-conjugating enzyme E2 (Ube2c), Centromere Protein E (Cenpe), Hyaluronan Synthase 2 (Has2), and CAMP Responsive Element Binding Protein 3 Like 2 (Creb3l2). This

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